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pubmed-article:2250716pubmed:abstractTextThree structural motifs in the invariant chain (li) control the intracellular transport of class II major histocompatibility complex molecules. An endoplasmic reticulum retention signal in the full-length li suggests a role for li in the alpha-beta heterodimer assembly. Another signal motif directs a truncated li, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated li binds alpha-beta dimers, a third signal dominates, directing the complex by way of the Golgi to vesicles in the cell periphery, which may represent a subcompartment of recycling endosomes.lld:pubmed
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pubmed-article:2250716pubmed:articleTitleIntracellular transport of class II MHC molecules directed by invariant chain.lld:pubmed
pubmed-article:2250716pubmed:affiliationDepartment of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.lld:pubmed
pubmed-article:2250716pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2250716pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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