| pubmed-article:2249770 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C0017363 | lld:lifeskim |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C1421565 | lld:lifeskim |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2249770 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2249770 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2249770 | pubmed:dateCreated | 1991-1-16 | lld:pubmed |
| pubmed-article:2249770 | pubmed:abstractText | NF-E1, a DNA-binding protein that recognizes the general consensus motif WGATAR, is the first tissue-specific factor to be identified in erythroid cells. Using a probe from the murine GF-1 (NF-E1) cDNA clone, we isolated three homologous chicken cDNAs: One of these corresponds to an mRNA (NF-E1a) that is abundantly and exclusively expressed in erythroid cells; a second mRNA (NF-E1b) is also expressed in all developmental stages of erythroid cells but is additionally found in a limited subset of other chicken tissues; mRNA representative of a third gene (NF-E1c) is expressed only in definitive (adult) erythrocytes within the red cell lineage but is also abundantly expressed in T lymphocytes and brain. All NF-E1 proteins are highly conserved within the DNA-binding domain and bind to the consensus motif with similar affinities in vitro; they are also all stimulatory trans-acting factors in vivo. The factors differ quantitatively in their ability to trans-activate reporter genes in which the number and position of cognate binding sites is varied relative to the transcriptional initiation site. These data suggest that the NF-E1 consensus motif directs a broader and more complicated array of developmental transcriptional regulatory processes than has been assumed and that NF-E1c may play a unique regulatory role in the developing chicken brain and in T lymphocytes. | lld:pubmed |
| pubmed-article:2249770 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2249770 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2249770 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2249770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2249770 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2249770 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2249770 | pubmed:author | pubmed-author:YamamotoMM | lld:pubmed |
| pubmed-article:2249770 | pubmed:author | pubmed-author:BeugHH | lld:pubmed |
| pubmed-article:2249770 | pubmed:author | pubmed-author:EngelJ DJD | lld:pubmed |
| pubmed-article:2249770 | pubmed:author | pubmed-author:OrkinS HSH | lld:pubmed |
| pubmed-article:2249770 | pubmed:author | pubmed-author:KuL LLL | lld:pubmed |
| pubmed-article:2249770 | pubmed:author | pubmed-author:LeonardM WMW | lld:pubmed |
| pubmed-article:2249770 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2249770 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:2249770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2249770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2249770 | pubmed:pagination | 1650-62 | lld:pubmed |
| pubmed-article:2249770 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2249770 | pubmed:meshHeading | pubmed-meshheading:2249770-... | lld:pubmed |
| pubmed-article:2249770 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2249770 | pubmed:articleTitle | Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. | lld:pubmed |
| pubmed-article:2249770 | pubmed:affiliation | Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208-3500. | lld:pubmed |
| pubmed-article:2249770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2249770 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2249770 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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