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| pubmed-article:2246248 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:2246248 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:2246248 | pubmed:dateCreated | 1991-1-8 | lld:pubmed |
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| pubmed-article:2246248 | pubmed:abstractText | Cartilage matrix protein (CMP) is a major component of the extracellular matrix of nonarticular cartilage. The structure and chromosomal location of the human gene encoding CMP was determined by molecular cloning analysis. We used a partial chicken CMP cDNA probe to isolate three overlapping human genomic clones. From one of these clones, a probe containing 2 human CMP exons was isolated and used to map the gene to chromosome 1p35 and to screen a human retina cDNA library. Two overlapping cDNA clones were isolated. The predicted protein sequence of 496 amino acids includes a 22-residue signal peptide and a 474-residue mature protein of Mr 51,344. The human CMP gene and polypeptide are strikingly similar to the chicken CMP gene and polypeptide. Human CMP is 79% identical to chicken CMP and contains two homologous domains separated by an epidermal growth factor-like domain. One potential N-glycosylation site is conserved between the two species. The human CMP gene spans 12 kilobase pairs with 8 exons and 7 introns which are similar in size to those of the chicken CMP gene. Both RNA splice junctions of intron G in the human and chicken CMP genes are nonconforming to the consensus splice sequences. This suggests that the CMP gene utilizes a new RNA splicing mechanism. | lld:pubmed |
| pubmed-article:2246248 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246248 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2246248 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2246248 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2246248 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2246248 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2246248 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:ShowsT BTB | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:ByersM GMG | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:JenkinsR NRN | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:GiróAA | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:FeilG HGH | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:SinclairA KAK | lld:pubmed |
| pubmed-article:2246248 | pubmed:author | pubmed-author:Osborne-Lawre... | lld:pubmed |
| pubmed-article:2246248 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2246248 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2246248 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:2246248 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2246248 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2246248 | pubmed:pagination | 19624-31 | lld:pubmed |
| pubmed-article:2246248 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2246248 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2246248 | pubmed:articleTitle | Structure and chromosomal location of the human gene encoding cartilage matrix protein. | lld:pubmed |
| pubmed-article:2246248 | pubmed:affiliation | Harold C. Simmons Arthritis Research Center, Dallas, Texas. | lld:pubmed |
| pubmed-article:2246248 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2246248 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2246248 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2246248 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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