| pubmed-article:2243391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C0459385 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C1336965 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C0242732 | lld:lifeskim |
| pubmed-article:2243391 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:2243391 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2243391 | pubmed:dateCreated | 1990-12-31 | lld:pubmed |
| pubmed-article:2243391 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2243391 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) strains isolated from the central nervous system (CNS) may represent a subgroup that displays a host cell tropism different from those isolated from peripheral blood and lymph nodes. One CNS-derived isolate, HIV-1SF128A, which can be propagated efficiently in primary macrophage culture but not in any T-cell lines, was molecularly cloned and characterized. Recombinant viruses between HIV-1SF128A and the peripheral blood isolate HIV-1SF2 were generated in order to map the viral gene(s) responsible for the macrophage tropism. The env gene sequences of the two isolates are about 91.1% homologous, with variations scattered mainly in the hypervariable regions of gp120. Recombinant viruses that have acquired the HIV-1SF128A env gene display HIV-1SF128A tropism for macrophages. Furthermore, the gp120 variable domains, V1, V2, V4, and V5, the CD4-binding domain, and the gp41 fusion domain are not directly involved in determining macrophage tropism. | lld:pubmed |
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| pubmed-article:2243391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2243391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2243391 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2243391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2243391 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2243391 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:2243391 | pubmed:author | pubmed-author:WoodCC | lld:pubmed |
| pubmed-article:2243391 | pubmed:author | pubmed-author:LevyJ AJA | lld:pubmed |
| pubmed-article:2243391 | pubmed:author | pubmed-author:TEET STS | lld:pubmed |
| pubmed-article:2243391 | pubmed:author | pubmed-author:Cheng-MayerCC | lld:pubmed |
| pubmed-article:2243391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2243391 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:2243391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2243391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2243391 | pubmed:pagination | 6148-53 | lld:pubmed |
| pubmed-article:2243391 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2243391 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2243391 | pubmed:articleTitle | The viral envelope gene is involved in macrophage tropism of a human immunodeficiency virus type 1 strain isolated from brain tissue. | lld:pubmed |
| pubmed-article:2243391 | pubmed:affiliation | Department of Microbiology, University of Kansas, Lawrence 66045-2103. | lld:pubmed |
| pubmed-article:2243391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2243391 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2243391 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2243391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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