| pubmed-article:224078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:224078 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:224078 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:224078 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:224078 | lifeskim:mentions | umls-concept:C1159689 | lld:lifeskim |
| pubmed-article:224078 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:224078 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:224078 | pubmed:dateCreated | 1979-10-26 | lld:pubmed |
| pubmed-article:224078 | pubmed:abstractText | Phytohemagglutinin (PHA) or concanavalin A treatment of lymphocytes causes an increase in membrane permeability so that the leak rates of Na and K increase 1.5- to 2-fold. Active Na and K transport increase proportionately in response to the increased membrane permeability. We have examined the role of lymphocyte Na concentration in sustaining the increased Na and K transport observed after PHA treatment. Cell Na concentration increases from 14.8 to 20.5 mmol/liter cell water in PHA-treated lymphocytes (P < 0.001). Four lines of evidence suggest that the 5-6 mmol/liter cell water increase in lymphocyte Na accounts for the increase in active Na and K transport in mitogen-treated lymphocytes. First, PHA does not increase directly the maximal Na, K-ATPase activity of isolated lymphocyte membrane vesicles. Second, when the Na concentration is increased by 6 mmol/liter cell water in unstimulated lymphocytes, Na and K transport increase nearly twofold. Third, the cell Na concentration (15 mmol/liter cell water) is near the K(m) for Na activation of the Na, K-ATPase in lymphocyte membranes. The ATPase activity thus, is capable of increasing as the cell Na rises above normal. Fourth, if lymphocytes are incubated in a medium containing a low Na concentration, K transport does not maintain the internal K concentration and the fall in cell K is accentuated in PHA-treated lymphocytes. These studies indicate that the adaptive acceleration of Na and K transport in mitogen-treated lymphocytes is mediated by a small increase in cell Na. | lld:pubmed |
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| pubmed-article:224078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:224078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:224078 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:224078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:224078 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:224078 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:224078 | pubmed:author | pubmed-author:LichtmanM AMA | lld:pubmed |
| pubmed-article:224078 | pubmed:author | pubmed-author:SimonWW | lld:pubmed |
| pubmed-article:224078 | pubmed:author | pubmed-author:ScanuMM | lld:pubmed |
| pubmed-article:224078 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:224078 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:224078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:224078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:224078 | pubmed:pagination | 834-41 | lld:pubmed |
| pubmed-article:224078 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:224078 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:224078 | pubmed:articleTitle | Regulation of sodium and potassium transport in phytohemagglutinin-stimulated human blood lymphocytes. | lld:pubmed |
| pubmed-article:224078 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:224078 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:224078 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:224078 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:224078 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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