| pubmed-article:2239366 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2239366 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2239366 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:2239366 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:2239366 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:2239366 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:2239366 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:2239366 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2239366 | pubmed:dateCreated | 1990-12-7 | lld:pubmed |
| pubmed-article:2239366 | pubmed:abstractText | Transforming growth factor beta (TGF-beta) has multiple effects on bone cell metabolism in vitro but its exact role in bone remodeling still needs to be defined. Here we demonstrate that TGF-beta is chemotactic for osteoblastlike cells from fetal rat calvariae and osteoblastlike ROS 17/2.8 osteosarcoma cells. Maximal chemotaxis occurred at 5-15 pg/ml of TGF-beta and was observed with TGF-beta 1 and TGF-beta 2 at equivalent concentrations. Conditioned medium from osteoblastlike cells containing latent TGF-beta failed to stimulate chemotactic migration. However, chemotactic activity was observed in conditioned medium that had been transiently acidified. Since acidification is known to activate TGF-beta, these results suggest that only active TGF-beta is capable of inducing a chemotactic response. Preincubation of osteoblastlike cells with TGF-beta in concentrations from 10 pg/ml to 1 ng/ml for 48 h abolished a subsequent chemotactic response of these cells to TGF-beta, indicating that TGF-beta-induced chemotaxis is a transient phenomenon. Since TGF-beta may be released from the bone matrix and/or activated during bone resorption, the chemotactic activity of TGF-beta for osteoblastlike cells may be important for the recruitment of osteoblastlike cells to sites of bone remodeling. | lld:pubmed |
| pubmed-article:2239366 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2239366 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2239366 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2239366 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2239366 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2239366 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2239366 | pubmed:issn | 0884-0431 | lld:pubmed |
| pubmed-article:2239366 | pubmed:author | pubmed-author:ZieglerRR | lld:pubmed |
| pubmed-article:2239366 | pubmed:author | pubmed-author:MundyG RGR | lld:pubmed |
| pubmed-article:2239366 | pubmed:author | pubmed-author:WolfOO | lld:pubmed |
| pubmed-article:2239366 | pubmed:author | pubmed-author:NaumannAA | lld:pubmed |
| pubmed-article:2239366 | pubmed:author | pubmed-author:Pfeilschifter... | lld:pubmed |
| pubmed-article:2239366 | pubmed:author | pubmed-author:MinneH WHW | lld:pubmed |
| pubmed-article:2239366 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2239366 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:2239366 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2239366 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2239366 | pubmed:pagination | 825-30 | lld:pubmed |
| pubmed-article:2239366 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:meshHeading | pubmed-meshheading:2239366-... | lld:pubmed |
| pubmed-article:2239366 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2239366 | pubmed:articleTitle | Chemotactic response of osteoblastlike cells to transforming growth factor beta. | lld:pubmed |
| pubmed-article:2239366 | pubmed:affiliation | Department of Medicine I, Endocrinology, University of Heidelberg, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:2239366 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2239366 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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