| pubmed-article:2234106 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C0010762 | lld:lifeskim |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C0023870 | lld:lifeskim |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C0439590 | lld:lifeskim |
| pubmed-article:2234106 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:2234106 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2234106 | pubmed:dateCreated | 1990-12-27 | lld:pubmed |
| pubmed-article:2234106 | pubmed:abstractText | The aim of this study was to investigate imipramine-induced alterations of cytochrome P-450 and to determine whether prolonged concomitant administration of imipramine and lithium results in a pharmacokinetic interaction. Male Wistar rats received imipramine (10 mg/kg i.p.) at 12 h intervals or lithium chloride (100 mg/kg in drinking water) or they were treated with the combination of these drugs for 2 weeks. The long term treatment with imipramine produced a very complex alteration of cytochrome P-450: imipramine increased the level of the cytochrome, but it decreased the rate of its own aromatic hydroxylation in position 2. The rate of N-demethylation in the side chain was not changed. Consequently, in the case of both hydroxylation and demethylation, calculated molecular activities were decreased to 48% and 70% respectively. This differential change in activities corresponded well to the observed decrease of absorption in difference spectra (type I) produced in microsomes by imipramine. Carbamazepine-induced type I difference spectra were also decreased by imipramine pretreatment, but to a lesser extent. In contrast, hexobarbital type I binding was increased by imipramine treatment while type II difference spectra produced by metyrapone were not affected. The preliminary SDS-PAGE analysis of cytochrome P-450 isoenzymes of control and imipramine treated rats showed that the investigated antidepressant markedly intensified a protein band at 50.11 kD while bands at 51.28 kD, 56.20 kD and 56.88 kD were less intensive. These results indicate that the alteration of cytochrome P-450 by imipramine treatment is not only of quantitative but also of qualitative character. Lithium alone given to rats affected neither the concentration of cytochrome P-450 in microsomal protein nor the rate of imipramine metabolism in vitro. Lithium given jointly with imipramine reduced imipramine-induced elevation of cytochrome P-450.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2234106 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2234106 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2234106 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2234106 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2234106 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:2234106 | pubmed:author | pubmed-author:NetterK JKJ | lld:pubmed |
| pubmed-article:2234106 | pubmed:author | pubmed-author:DanielWW | lld:pubmed |
| pubmed-article:2234106 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2234106 | pubmed:volume | 342 | lld:pubmed |
| pubmed-article:2234106 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2234106 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2234106 | pubmed:pagination | 234-40 | lld:pubmed |
| pubmed-article:2234106 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2234106 | pubmed:meshHeading | pubmed-meshheading:2234106-... | lld:pubmed |
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| pubmed-article:2234106 | pubmed:meshHeading | pubmed-meshheading:2234106-... | lld:pubmed |
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| pubmed-article:2234106 | pubmed:meshHeading | pubmed-meshheading:2234106-... | lld:pubmed |
| pubmed-article:2234106 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2234106 | pubmed:articleTitle | Alteration of cytochrome P-450 by prolonged administration of imipramine and/or lithium to rats. | lld:pubmed |
| pubmed-article:2234106 | pubmed:affiliation | Department of Pharmacology and Toxicology, University of Marburg, Medical School, Federal Republic of Germany. | lld:pubmed |
| pubmed-article:2234106 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2234106 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2234106 | lld:pubmed |
