| pubmed-article:2233709 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2233709 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2233709 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:2233709 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2233709 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2233709 | lifeskim:mentions | umls-concept:C0205198 | lld:lifeskim |
| pubmed-article:2233709 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2233709 | pubmed:dateCreated | 1990-12-5 | lld:pubmed |
| pubmed-article:2233709 | pubmed:abstractText | We have found that the mouse metallothionein-I (MT-I) gene promoter functions in an unusual, compound manner. It directs both TATA-dependent and TATA-independent modes of transcription in vivo. The TATA-dependent message is initiated at the previously characterized +1 transcription start site and is the predominant species in most tissues. In many cell types it is metal inducible. The TATA-independent initiation sites are distributed over the 160 bp upstream of the previously characterized +1 start site, and the RNA products are present in all tissues examined. Only in testis, however, do the TATA-independent transcripts predominate, accumulating to highest levels in pachytene-stage meiotic cells and early spermatids. Unlike the TATA-dependent +1 transcript, these RNAs are not induced by metal, even in cultured cells in which the +1 species is induced. Transfection studies of site-directed mutants show that destruction of the TATA element drastically alters the ratio of the two RNA classes in cells in which the +1 transcripts normally dominates. In TATA-minus mutants, the TATA-independent RNAs become the most prevalent, although they remain refractory to metal induction. Thus, the MT-I promoter utilizes two different types of core promoter function within a single cell population. The two different types of core promoter respond very differently to environmental stimuli, and the choice between them appears to be regulated in a tissue-specific fashion. | lld:pubmed |
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| pubmed-article:2233709 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2233709 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2233709 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2233709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2233709 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2233709 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2233709 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2233709 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2233709 | pubmed:author | pubmed-author:GarrettD JDJ | lld:pubmed |
| pubmed-article:2233709 | pubmed:author | pubmed-author:WoldB JBJ | lld:pubmed |
| pubmed-article:2233709 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2233709 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2233709 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2233709 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2233709 | pubmed:pagination | 5646-54 | lld:pubmed |
| pubmed-article:2233709 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2233709 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2233709 | pubmed:articleTitle | Tissue-specific expression from a compound TATA-dependent and TATA-independent promoter. | lld:pubmed |
| pubmed-article:2233709 | pubmed:affiliation | Division of Biology, California Institute of Technology, Pasadena 91125. | lld:pubmed |
| pubmed-article:2233709 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2233709 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2233709 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
