| pubmed-article:2231432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C1704336 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C1413043 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C1554158 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:2231432 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:2231432 | pubmed:dateCreated | 1990-12-19 | lld:pubmed |
| pubmed-article:2231432 | pubmed:abstractText | 1. The rate constant of tension redevelopment (ktr) following a rapid release and subsequent re-extension of muscle length has been demonstrated to be Ca2+ sensitive and is thought to reflect the rate-limiting step in the cross-bridge cycle leading to the formation of the strongly bound, force-bearing state. The kinetics of this cross-bridge state transition were investigated at 15 degrees C over a wide range of Ca2+ concentrations while varying pH from 7.00 to 6.20 in rat slow-twitch soleus, rat fast-twitch superficial vastus lateralis (SVL) and rabbit fast-twitch psoas skinned single fibres. 2. At maximal levels of Ca2+ activation, ktr was unaffected by changes in pH from 7.00 to 6.20 while isometric tension was depressed to 0.60 +/- 0.02 P0 (mean +/- S.E.M.) at the low pH in fast-twitch fibres and to 0.78 +/- 0.01 P0 in slow-twitch fibres (P0 is the maximum isometric tension obtained at pH 7.00). 3. At reduced levels of Ca2+ activation, corresponding to pCa (-log [Ca2+]) greater than 5.0, ktr was markedly depressed in all fibre types when pH was lowered. The Ca2+ sensitivity of steady-state isometric tension was also reduced in all fibres at pH 6.20 compared to pH 7.00. 4. The results suggest that pH has a modulatory effect upon an apparent rate constant which is rate limiting in terms of the formation of the strongly bound, force-bearing cross-bridge state. This effect of altered pH may in part account for the reduction in the Ca2+ sensitivity of isometric force at low pH as well as the depression of the rate of rise of tension in living fibres during fatiguing stimulation. | lld:pubmed |
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| pubmed-article:2231432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2231432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2231432 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2231432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2231432 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2231432 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:2231432 | pubmed:author | pubmed-author:MossR LRL | lld:pubmed |
| pubmed-article:2231432 | pubmed:author | pubmed-author:MetzgerJ MJM | lld:pubmed |
| pubmed-article:2231432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2231432 | pubmed:volume | 428 | lld:pubmed |
| pubmed-article:2231432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2231432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2231432 | pubmed:pagination | 751-64 | lld:pubmed |
| pubmed-article:2231432 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2231432 | pubmed:meshHeading | pubmed-meshheading:2231432-... | lld:pubmed |
| pubmed-article:2231432 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2231432 | pubmed:articleTitle | pH modulation of the kinetics of a Ca2(+)-sensitive cross-bridge state transition in mammalian single skeletal muscle fibres. | lld:pubmed |
| pubmed-article:2231432 | pubmed:affiliation | Department of Physiology, School of Medicine, University of Wisconsin, Madison 53706. | lld:pubmed |
| pubmed-article:2231432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2231432 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2231432 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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