| pubmed-article:2230601 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C0028167 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C0069477 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C0151763 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C0699857 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:2230601 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2230601 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2230601 | pubmed:dateCreated | 1990-12-26 | lld:pubmed |
| pubmed-article:2230601 | pubmed:abstractText | Attempts were made to promote or inhibit nitric oxide (. N = O) synthesis in a murine model of hepatic damage (Corynebacterium parvum followed by lipopolysaccharide; LPS) to determine the role of . N = O in the liver injury. Moderate hepatic damage and increases in circulating NO2-/NO3- levels were detectable after C. parvum alone. Administration of LPS to these mice resulted in severe hepatic damage and acute elevations in circulating nitrogen oxide levels. L-arg had no influence on the C. parvum or LPS-induced changes. NG-monomethyl-L-arginine (NMA) had no effect in the absence of LPS, but when given with LPS, a dose-dependent suppression in plasma NO2-/NO3- levels and an increase in liver injury were seen. The NMA-induced changes were partially reversed by the simultaneous administration of L-arg. These findings suggest a protective role for . N = O in this model. | lld:pubmed |
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| pubmed-article:2230601 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2230601 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2230601 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2230601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2230601 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2230601 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2230601 | pubmed:issn | 0741-5400 | lld:pubmed |
| pubmed-article:2230601 | pubmed:author | pubmed-author:SimmonsR LRL | lld:pubmed |
| pubmed-article:2230601 | pubmed:author | pubmed-author:BilliarT RTR | lld:pubmed |
| pubmed-article:2230601 | pubmed:author | pubmed-author:CurranR DRD | lld:pubmed |
| pubmed-article:2230601 | pubmed:author | pubmed-author:HarbrechtB... | lld:pubmed |
| pubmed-article:2230601 | pubmed:author | pubmed-author:DemetrisA JAJ | lld:pubmed |
| pubmed-article:2230601 | pubmed:author | pubmed-author:StuehrD JDJ | lld:pubmed |
| pubmed-article:2230601 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2230601 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:2230601 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2230601 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2230601 | pubmed:pagination | 565-9 | lld:pubmed |
| pubmed-article:2230601 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2230601 | pubmed:meshHeading | pubmed-meshheading:2230601-... | lld:pubmed |
| pubmed-article:2230601 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2230601 | pubmed:articleTitle | Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage. | lld:pubmed |
| pubmed-article:2230601 | pubmed:affiliation | Department of Surgery, University of Pittsburgh, PA 15261. | lld:pubmed |
| pubmed-article:2230601 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2230601 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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