| pubmed-article:2226828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2226828 | lifeskim:mentions | umls-concept:C0003232 | lld:lifeskim |
| pubmed-article:2226828 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:2226828 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:2226828 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:2226828 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2226828 | pubmed:dateCreated | 1990-12-13 | lld:pubmed |
| pubmed-article:2226828 | pubmed:abstractText | The interaction of a new group of 'quinomycin-like' antibiotics with the DNA duplexes d(ACGT)2 and d(GACGTC)2 has been investigated in solution by 1H NMR spectroscopy. By monitoring the intensity of intranucleotide base H6/H8 to deoxyribose H1'NOE cross-peaks we conclude that the terminal A-T basepairs flanking the CG bisintercalation site in the d(ACGT)2 complex adopt the Hoogsteen bonding scheme, with the purine base in a syn conformation. By comparison in the d(GACGTC)2 complex all glycosidic bond angles are anti, consistent with a preferred Watson-Crick basepairing scheme. Both DNA duplexes appear to be significantly unwound compared with the ligand-free DNAs. The data illustrate the influence of helical constraints on the stability of the Hoogsteen bonding scheme adjacent to the drug binding sites. | lld:pubmed |
| pubmed-article:2226828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2226828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2226828 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2226828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2226828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2226828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2226828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2226828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2226828 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2226828 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:2226828 | pubmed:author | pubmed-author:WickhamGG | lld:pubmed |
| pubmed-article:2226828 | pubmed:author | pubmed-author:SearleM SMS | lld:pubmed |
| pubmed-article:2226828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2226828 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2226828 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:2226828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2226828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2226828 | pubmed:pagination | 171-4 | lld:pubmed |
| pubmed-article:2226828 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:meshHeading | pubmed-meshheading:2226828-... | lld:pubmed |
| pubmed-article:2226828 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2226828 | pubmed:articleTitle | Hoogsteen versus Watson-Crick A-T basepairing in DNA complexes of a new group of 'quinomycin-like' antibiotics. | lld:pubmed |
| pubmed-article:2226828 | pubmed:affiliation | Peter MacCallum Cancer Institute NMR Facility, Victorian College of Pharmacy, Parkville, Australia. | lld:pubmed |
| pubmed-article:2226828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2226828 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2226828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2226828 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2226828 | lld:pubmed |
