| pubmed-article:2225314 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C0076080 | lld:lifeskim |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:2225314 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:2225314 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2225314 | pubmed:dateCreated | 1990-12-4 | lld:pubmed |
| pubmed-article:2225314 | pubmed:abstractText | The experimental antineoplastic agent temozolomide was not metabolised in vitro at a measurable rate by mouse liver fractions. In contrast, the temozolomide analogue 3-methylbenzotriazinone was metabolically N-demethylated by hepatic microsomes to yield benzotriazinone. The major route of excretion of [14C]-labelled temozolomide in mice was via the kidneys. An acidic metabolite of temozolomide, probably a conjugate, was found in the urine of mice, but its identity could not be established unambiguously. Spectroscopic analysis and chemical tests revealed that it possesses an intact NNN-linkage. Another metabolite was found in the urine of patients but not of mice. This metabolite was identified as the 8-carboxylic acid derivative of temozolomide. Unlike the unknown species, this metabolite was cytotoxic against TLX5 lymphoma cells in vitro. | lld:pubmed |
| pubmed-article:2225314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2225314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2225314 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2225314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2225314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2225314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2225314 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2225314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2225314 | pubmed:issn | 0344-5704 | lld:pubmed |
| pubmed-article:2225314 | pubmed:author | pubmed-author:GescherAA | lld:pubmed |
| pubmed-article:2225314 | pubmed:author | pubmed-author:SlackJ AJA | lld:pubmed |
| pubmed-article:2225314 | pubmed:author | pubmed-author:FarmerP BPB | lld:pubmed |
| pubmed-article:2225314 | pubmed:author | pubmed-author:TsangL LLL | lld:pubmed |
| pubmed-article:2225314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2225314 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:2225314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2225314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2225314 | pubmed:pagination | 429-36 | lld:pubmed |
| pubmed-article:2225314 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2225314 | pubmed:meshHeading | pubmed-meshheading:2225314-... | lld:pubmed |
| pubmed-article:2225314 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2225314 | pubmed:articleTitle | Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity. | lld:pubmed |
| pubmed-article:2225314 | pubmed:affiliation | Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, England, U.K. | lld:pubmed |
| pubmed-article:2225314 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2225314 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2225314 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2225314 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2225314 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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