| pubmed-article:2221104 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2221104 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2221104 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:2221104 | lifeskim:mentions | umls-concept:C0035094 | lld:lifeskim |
| pubmed-article:2221104 | lifeskim:mentions | umls-concept:C1882714 | lld:lifeskim |
| pubmed-article:2221104 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:2221104 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:2221104 | pubmed:dateCreated | 1990-11-19 | lld:pubmed |
| pubmed-article:2221104 | pubmed:abstractText | To define whether angiotensin I-converting enzyme (ACE) inhibition affects the distribution of renin gene-expressing cells within the kidney, a control group of adult male Wistar-Kyoto rats (C, n = 7) was compared with a group of rats treated with enalapril (E, n = 6) for 5 days. Renin mRNA distribution was assessed using in situ hybridization to a 35S-labeled 28 mer oligonucleotide complementary to rat renin mRNA. Whereas in control rats renin mRNA was confined to a juxtaglomerular location, in enalapril-treated rats, renin mRNA extended proximally along the length of the afferent arteriole. The percent of visible afferent arteriolar length containing renin mRNA was higher in enalapril-treated (71.7 +/- 2.8%) than in control (49.6 +/- 2.1%) rats (P less than 0.0001). These findings were accompanied by an increase in the percent of juxtaglomerular apparatuses (JGAs) containing renin mRNA (71 +/- 2.2 vs. 49 +/- 2.9%; E vs. C, P less than 0.0001). Also, the intensity of the JGA hybridization signals was higher in enalapril-treated (757 +/- 59 grains/JGA) than in control (167 +/- 11 grains/JGA) rats (P less than 0.00001). We conclude that the increased kidney renin gene expression elicited by ACE inhibition is the result of an increase in renin mRNA content per JGA, an increase in the number of JGAs expressing the renin gene, and a recruitment of renin gene-expressing cells along the afferent arteriole. | lld:pubmed |
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| pubmed-article:2221104 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2221104 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2221104 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2221104 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2221104 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2221104 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2221104 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2221104 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2221104 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:PeachM JMJ | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:CareyR MRM | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:LynchK RKR | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:ChevalierR... | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:GomezR ARA | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:EverettA DAD | lld:pubmed |
| pubmed-article:2221104 | pubmed:author | pubmed-author:ElwoodJ PJP | lld:pubmed |
| pubmed-article:2221104 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2221104 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:2221104 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2221104 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2221104 | pubmed:pagination | F660-5 | lld:pubmed |
| pubmed-article:2221104 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2221104 | pubmed:meshHeading | pubmed-meshheading:2221104-... | lld:pubmed |
| pubmed-article:2221104 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2221104 | pubmed:articleTitle | Recruitment of renin gene-expressing cells in adult rat kidneys. | lld:pubmed |
| pubmed-article:2221104 | pubmed:affiliation | Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908. | lld:pubmed |
| pubmed-article:2221104 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2221104 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2221104 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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