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pubmed-article:2213160pubmed:abstractTextCytogenetic studies of three rare childhood brain tumors were performed. Two children presented with pure rhabdoid tumors. The third child had a tumor composed of a mixture of rhabdoid elements with neuroepithelial, epithelial, and mesenchymal tissue - an atypical teratoid tumor. All three tumors demonstrated monosomy 22 as the only cytogenetic abnormality. The cytogenetic findings suggest that loss of a gene or genes on chromosome 22 may be involved in the initiation or progression of these malignant tumors. Further studies on additional fresh tumor specimens are warranted; however, it is possible that cytogenetic studies may be used as an additional means of diagnosing rhabdoid or atypical teratoid tumors of the brain.lld:pubmed
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pubmed-article:2213160pubmed:articleTitleMonosomy 22 in rhabdoid or atypical tumors of the brain.lld:pubmed
pubmed-article:2213160pubmed:affiliationDivision of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Pennsylvania.lld:pubmed
pubmed-article:2213160pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2213160pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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