| pubmed-article:2212951 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2212951 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:2212951 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:2212951 | lifeskim:mentions | umls-concept:C0879590 | lld:lifeskim |
| pubmed-article:2212951 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:2212951 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2212951 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:2212951 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2212951 | pubmed:dateCreated | 1990-11-1 | lld:pubmed |
| pubmed-article:2212951 | pubmed:abstractText | To study the effects of localized secretion of cytokines on tumor progression, the gene for human interleukin 2 (IL-2) was introduced via retroviral vectors into CMS-5 cells, a weakly immunogenic mouse fibrosarcoma cell line of BALB/c origin. Secretion of low levels of IL-2 from the tumor cells abrogated their tumorigenicity and induced a long-lasting protective immune response against a challenge with a tumorigenic dose of parental CMS-5 cells. Co-injection of IL-2-producing CMS-5 cells with unmodified tumor cells inhibited tumor formation even when highly tumorigenic doses of CMS-5 cells were used. Cytolytic activity in mice injected with parental CMS-5 cells was transient and was greatly diminished 3 wk after injection, as commonly observed in tumor-bearing animals. However, in mice injected with IL-2-producing cells, tumor-specific cytolytic activity persisted at high levels for the duration of the observation period (at least 75 d). High levels of tumor-specific cytolytic activity could also be detected in parental CMS-5 tumor-bearing animals 18 d after inoculation with tumor cells, if IL-2-producing CMS-5 cells but not unmodified parental tumor cells were used as targets. These studies highlight the potential advantages of localized secretion of cytokines mediated via gene transfer to induce potent anti-tumor immune responses. | lld:pubmed |
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| pubmed-article:2212951 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2212951 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2212951 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2212951 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2212951 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2212951 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2212951 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2212951 | pubmed:author | pubmed-author:GilboaEE | lld:pubmed |
| pubmed-article:2212951 | pubmed:author | pubmed-author:ZierKK | lld:pubmed |
| pubmed-article:2212951 | pubmed:author | pubmed-author:DanielsBB | lld:pubmed |
| pubmed-article:2212951 | pubmed:author | pubmed-author:CroninKK | lld:pubmed |
| pubmed-article:2212951 | pubmed:author | pubmed-author:GansbacherBB | lld:pubmed |
| pubmed-article:2212951 | pubmed:author | pubmed-author:BannerjiRR | lld:pubmed |
| pubmed-article:2212951 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2212951 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2212951 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:2212951 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2212951 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2212951 | pubmed:pagination | 1217-24 | lld:pubmed |
| pubmed-article:2212951 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2212951 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2212951 | pubmed:articleTitle | Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. | lld:pubmed |
| pubmed-article:2212951 | pubmed:affiliation | Department of Hematology/Lymphoma, Memorial-Sloan Kettering Cancer Center, New York, New York 10021. | lld:pubmed |
| pubmed-article:2212951 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2212951 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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