| pubmed-article:2209695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:2209695 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:2209695 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2209695 | pubmed:dateCreated | 1990-11-21 | lld:pubmed |
| pubmed-article:2209695 | pubmed:abstractText | We analyzed the effects of interleukin 2 (IL 2) and IL 4 isolated and in association on the specific response of human B cells triggered by trinitrophenylated polyacrylamide beads (TNP-PAA). IL 2 induced an increase (more than 10 times) in the number of hapten-binding cells [detected by a rosette-forming cell (RFC) assay] as well as the generation of antibody-producing cells [detected by a plaque-forming cell (PFC) assay]. IL 4 induced an isolated RFC response without PFC response. We verified that the IL 4 (as well as 12)-induced RFC were hapten specific and mediated through membrane IgM. Density fractionation experiments showed that IL 4-induced RFC were equally distributed between high-density and intermediate-density B cells. IL 2 appeared to drive more B cells into the intermediate density fraction. IL 2-induced PFC belonged to the RFC population and were intermediate-size B cells. IL 2 drove more RFC into an activated stage and it induced the differentiation of a number of them into antibody-producing cells. The evaluation of the proportion of RFC able to incorporate thymidine showed that both IL induced a substantial proliferation of antigen-activated B cells. However, IL 4 inhibited the IL 2-dependent PFC without affecting the number of RFC nor the proportion of proliferating RFC induced by this IL. These results directly demonstrate that human IL 4 triggers the expansion of antigen-activated B cells and selectively inhibits the IL 2-induced differentiation. | lld:pubmed |
| pubmed-article:2209695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2209695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209695 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2209695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2209695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2209695 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2209695 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:2209695 | pubmed:author | pubmed-author:GalanaudPP | lld:pubmed |
| pubmed-article:2209695 | pubmed:author | pubmed-author:CrevonM CMC | lld:pubmed |
| pubmed-article:2209695 | pubmed:author | pubmed-author:LlorenteLL | lld:pubmed |
| pubmed-article:2209695 | pubmed:author | pubmed-author:MitjavilaFF | lld:pubmed |
| pubmed-article:2209695 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2209695 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:2209695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2209695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2209695 | pubmed:pagination | 1887-92 | lld:pubmed |
| pubmed-article:2209695 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:meshHeading | pubmed-meshheading:2209695-... | lld:pubmed |
| pubmed-article:2209695 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2209695 | pubmed:articleTitle | Dual effects of interleukin 4 on antigen-activated human B cells: induction of proliferation and inhibition of interleukin 2-dependent differentiation. | lld:pubmed |
| pubmed-article:2209695 | pubmed:affiliation | INSERM U 131, Clamart, France. | lld:pubmed |
| pubmed-article:2209695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2209695 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2209695 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2209695 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2209695 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2209695 | lld:pubmed |
