| pubmed-article:2203970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2203970 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:2203970 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2203970 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2203970 | pubmed:issue | 6289 | lld:pubmed |
| pubmed-article:2203970 | pubmed:dateCreated | 1990-10-11 | lld:pubmed |
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| pubmed-article:2203970 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2203970 | pubmed:abstractText | Patchwork homology observed between divergent members of polymorphic multigene families is thought to reflect evolution by short-tract gene conversion (nonreciprocal recombination), although this mechanism cannot usually be confirmed in higher organisms. In contrast to meiotic conversions observed in laboratory yeast strains, apparent conversions between polymorphic sequences, such as the class I loci of the major histocompatibility complex (MHC), are short and do not seem to be associated with reciprocal recombination (crossover, exchanges). We have now integrated two nonallelic murine class I genes into yeast to characterize their meiotic recombination. We found no crossovers between the MHC genes, but short-tract 'microconversions' of 1-215 base-pairs were observed in about 6% of all meioses. Strikingly, one of these events was accompanied by a single base-pair mutation. These results underscore both the importance of meiotic gene conversion and sequence heterology in determining conversion patterns between divergent genes. | lld:pubmed |
| pubmed-article:2203970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2203970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2203970 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2203970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2203970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2203970 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2203970 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2203970 | pubmed:author | pubmed-author:GoodenowR SRS | lld:pubmed |
| pubmed-article:2203970 | pubmed:author | pubmed-author:WheelerC JCJ | lld:pubmed |
| pubmed-article:2203970 | pubmed:author | pubmed-author:FogelSS | lld:pubmed |
| pubmed-article:2203970 | pubmed:author | pubmed-author:MaloneyDD | lld:pubmed |
| pubmed-article:2203970 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2203970 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:2203970 | pubmed:volume | 347 | lld:pubmed |
| pubmed-article:2203970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2203970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2203970 | pubmed:pagination | 192-4 | lld:pubmed |
| pubmed-article:2203970 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2203970 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2203970 | pubmed:articleTitle | Microconversion between murine H-2 genes integrated into yeast. | lld:pubmed |
| pubmed-article:2203970 | pubmed:affiliation | Department of Molecular and Cell Biology, University of California, Berkeley 94720. | lld:pubmed |
| pubmed-article:2203970 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2203970 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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