| pubmed-article:219253 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:219253 | lifeskim:mentions | umls-concept:C0369169 | lld:lifeskim |
| pubmed-article:219253 | lifeskim:mentions | umls-concept:C0007601 | lld:lifeskim |
| pubmed-article:219253 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:219253 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:219253 | pubmed:dateCreated | 1979-6-29 | lld:pubmed |
| pubmed-article:219253 | pubmed:abstractText | Micrococcal nuclease digestion was used to analyze Epstein-Barr virus (EBV) DNA structure in nuclei of transformed cells. Digests of virus-producing (P3HR-1), non-virus-producing (Raji), and superinfected Rajii cell nuclei were fractionated by electrophoresis on agarose gels, transferred to nitrocellulose, and hybridized to 32P-labeled EBV DNA. The viral DNA of Raji nuclei produced a series of bands on electrophoresis whose lengths were integral multiples of a unit size, which was the same as the repeat length of host DNA. Viral DNA in nuclei of P3HR-1 and superinfected Raji cells produced faintly visible bands superimposed on a smear of viral DNA which dominated the hybridization pattern. No differences were detected in the patterns when total DNA digests from Raji, P3HR-1, and an EBV DNA-negative cell line (U-698M) were analyzed by ethidium bromide staining or by hybridization with the use of 32P-labeled lymphoblastoid cell DNA as probe. We conclude that the EBV episomal DNA of Raji cells is folded into nucleosomes, whereas most of the viral DNA of P3HR-1 and superinfected Raji cells is not. This pattern of DNA organization differs signficantly from that in papova group viruses. | lld:pubmed |
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| pubmed-article:219253 | pubmed:language | eng | lld:pubmed |
| pubmed-article:219253 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:219253 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:219253 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:219253 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:219253 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:219253 | pubmed:author | pubmed-author:ShawJ EJE | lld:pubmed |
| pubmed-article:219253 | pubmed:author | pubmed-author:CarterC WCWJr | lld:pubmed |
| pubmed-article:219253 | pubmed:author | pubmed-author:LevingerL FLF | lld:pubmed |
| pubmed-article:219253 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:219253 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:219253 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:219253 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:219253 | pubmed:pagination | 657-65 | lld:pubmed |
| pubmed-article:219253 | pubmed:dateRevised | 2010-9-2 | lld:pubmed |
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| pubmed-article:219253 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:219253 | pubmed:articleTitle | Nucleosomal structure of Epstein-Barr virus DNA in transformed cell lines. | lld:pubmed |
| pubmed-article:219253 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:219253 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:219253 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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