| pubmed-article:21921156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21921156 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21921156 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
| pubmed-article:21921156 | lifeskim:mentions | umls-concept:C0042276 | lld:lifeskim |
| pubmed-article:21921156 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21921156 | lifeskim:mentions | umls-concept:C1709893 | lld:lifeskim |
| pubmed-article:21921156 | pubmed:issue | 6052 | lld:pubmed |
| pubmed-article:21921156 | pubmed:dateCreated | 2011-10-7 | lld:pubmed |
| pubmed-article:21921156 | pubmed:abstractText | Neural circuits regulate cytokine production to prevent potentially damaging inflammation. A prototypical vagus nerve circuit, the inflammatory reflex, inhibits tumor necrosis factor-? production in spleen by a mechanism requiring acetylcholine signaling through the ?7 nicotinic acetylcholine receptor expressed on cytokine-producing macrophages. Nerve fibers in spleen lack the enzymatic machinery necessary for acetylcholine production; therefore, how does this neural circuit terminate in cholinergic signaling? We identified an acetylcholine-producing, memory phenotype T cell population in mice that is integral to the inflammatory reflex. These acetylcholine-producing T cells are required for inhibition of cytokine production by vagus nerve stimulation. Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses. | lld:pubmed |
| pubmed-article:21921156 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21921156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21921156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21921156 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:21921156 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:MakTak WTW | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:PavlovValenti... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:OchaniMahenda... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:TraceyKevin... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:AnderssonUlfU | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:TuscheMichael... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:ChavanSangeet... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:OlofssonPeder... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:ReardonColinC | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:Rosas-Ballina... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:Valdés-Ferrer... | lld:pubmed |
| pubmed-article:21921156 | pubmed:author | pubmed-author:LevineYaakov... | lld:pubmed |
| pubmed-article:21921156 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21921156 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:21921156 | pubmed:volume | 334 | lld:pubmed |
| pubmed-article:21921156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21921156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21921156 | pubmed:pagination | 98-101 | lld:pubmed |
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| pubmed-article:21921156 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21921156 | pubmed:articleTitle | Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. | lld:pubmed |
| pubmed-article:21921156 | pubmed:affiliation | Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA. | lld:pubmed |
| pubmed-article:21921156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21921156 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21921156 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:12647 | entrezgene:pubmed | pubmed-article:21921156 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21921156 | lld:pubmed |
