| pubmed-article:21896938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21896938 | lifeskim:mentions | umls-concept:C0034715 | lld:lifeskim |
| pubmed-article:21896938 | lifeskim:mentions | umls-concept:C0003018 | lld:lifeskim |
| pubmed-article:21896938 | lifeskim:mentions | umls-concept:C0160420 | lld:lifeskim |
| pubmed-article:21896938 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:21896938 | lifeskim:mentions | umls-concept:C0215848 | lld:lifeskim |
| pubmed-article:21896938 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:21896938 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21896938 | pubmed:dateCreated | 2011-9-15 | lld:pubmed |
| pubmed-article:21896938 | pubmed:abstractText | Although it has been shown that upregulation of hypoxia-inducible factor (HIF)-1? is protective in acute ischemic renal injury, long-term overactivation of HIF-1? is implicated to be injurious in chronic kidney diseases. Angiotensin II (Ang II) is a well-known pathogenic factor producing chronic renal injury and has also been shown to increase HIF-1?. However, the contribution of HIF-1? to Ang II-induced renal injury has not been evidenced. The present study tested the hypothesis that HIF-1? mediates Ang II-induced renal injury in Sprague-Dawley rats. Chronic renal injury was induced by Ang II infusion (200 ng/kg per minute) for 2 weeks in uninephrectomized rats. Transfection of vectors expressing HIF-1? small hairpin RNA into the kidneys knocked down HIF-1? gene expression by 70%, blocked Ang II-induced HIF-1? activation, and significantly attenuated Ang II-induced albuminuria, which was accompanied by inhibition of Ang II-induced vascular endothelial growth factor, a known glomerular permeability factor, in glomeruli. HIF-1? small hairpin RNA also significantly improved the glomerular morphological damage induced by Ang II. Furthermore, HIF-1? small hairpin RNA blocked Ang II-induced upregulation of collagen and ?-smooth muscle actin in tubulointerstitial region. There was no difference in creatinine clearance and Ang II-induced increase in blood pressure. HIF-1? small hairpin RNA had no effect on Ang II-induced reduction in renal blood flow and hypoxia in the kidneys. These data suggested that overactivation of HIF-1?-mediated gene regulation in the kidney is a pathogenic pathway mediating Ang II-induced chronic renal injuries, and normalization of overactivated HIF-1? may be used as a treatment strategy for chronic kidney damages associated with excessive Ang II. | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21896938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21896938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21896938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21896938 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:21896938 | pubmed:issn | 1524-4563 | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:ToyP LPL | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:AbbateAntonio... | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:LiNingjunN | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:LiPin-LanPL | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:ZhuQingQ | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:WangZhengchao... | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:21896938 | pubmed:author | pubmed-author:DhadukRomeshR | lld:pubmed |
| pubmed-article:21896938 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21896938 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:21896938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21896938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21896938 | pubmed:pagination | 657-64 | lld:pubmed |
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| pubmed-article:21896938 | pubmed:meshHeading | pubmed-meshheading:21896938... | lld:pubmed |
| pubmed-article:21896938 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21896938 | pubmed:articleTitle | Silencing of hypoxia-inducible factor-1? gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats. | lld:pubmed |
| pubmed-article:21896938 | pubmed:affiliation | Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA. | lld:pubmed |
| pubmed-article:21896938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21896938 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:29560 | entrezgene:pubmed | pubmed-article:21896938 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21896938 | lld:entrezgene |
