| pubmed-article:21849681 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C0085494 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C1306235 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C1826449 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C0152060 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C1549649 | lld:lifeskim |
| pubmed-article:21849681 | lifeskim:mentions | umls-concept:C0205154 | lld:lifeskim |
| pubmed-article:21849681 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:21849681 | pubmed:dateCreated | 2011-9-8 | lld:pubmed |
| pubmed-article:21849681 | pubmed:abstractText | Nucleotide-binding oligomerization domain 2 (Nod2) mutations including L1007fsinsC are associated with the development of Crohn's disease (CD). These CD-associated Nod2 mutations are common in healthy white populations, suggesting that they may confer some protective function, but experimental evidence is lacking. Using a mouse strain that expresses Nod2(2939iCstop), the equivalent of the L1007fsinsC mutation, we found that macrophages homozygous for Nod2(2939iCstop) are impaired in the recognition of muramyl dipeptide and Enterococcus faecalis, a commensal bacterium that is a common cause of sepsis-associated lethality in humans. Notably, Nod2 deficiency and homozygocity for Nod2(2939iCstop) were associated with reduced production of TNF-? and IL-6 and lethality after systemic infection with E. faecalis despite normal bacteria loads. Consistently, inhibition of TNF-? signaling protected wild-type mice from E. faecalis-induced lethality. These results suggest that the same Nod2 mutation can increase the susceptibility to CD, but also protect the host from systemic infection by a common enteric bacterium. | lld:pubmed |
| pubmed-article:21849681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21849681 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21849681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21849681 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21849681 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21849681 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:OguraYasunori... | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:NúñezGabrielG | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:WarnerNeilN | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:ParkJong-Hwan... | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:ShawMichael... | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:ChenFeliciaF | lld:pubmed |
| pubmed-article:21849681 | pubmed:author | pubmed-author:KimYun-GiYG | lld:pubmed |
| pubmed-article:21849681 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21849681 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21849681 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:21849681 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21849681 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21849681 | pubmed:pagination | 2849-52 | lld:pubmed |
| pubmed-article:21849681 | pubmed:meshHeading | pubmed-meshheading:21849681... | lld:pubmed |
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| pubmed-article:21849681 | pubmed:meshHeading | pubmed-meshheading:21849681... | lld:pubmed |
| pubmed-article:21849681 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21849681 | pubmed:articleTitle | Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. | lld:pubmed |
| pubmed-article:21849681 | pubmed:affiliation | Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. | lld:pubmed |
| pubmed-article:21849681 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21849681 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21849681 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:257632 | entrezgene:pubmed | pubmed-article:21849681 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21849681 | lld:entrezgene |
