| pubmed-article:2184043 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2184043 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2184043 | lifeskim:mentions | umls-concept:C0020672 | lld:lifeskim |
| pubmed-article:2184043 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:2184043 | lifeskim:mentions | umls-concept:C0003596 | lld:lifeskim |
| pubmed-article:2184043 | lifeskim:mentions | umls-concept:C2584300 | lld:lifeskim |
| pubmed-article:2184043 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:2184043 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2184043 | pubmed:dateCreated | 1990-5-31 | lld:pubmed |
| pubmed-article:2184043 | pubmed:abstractText | Apomorphine and N-n-propylnorapomorphine (NPA) were compared for their ability to induce stereotyped cage climbing and hypothermia in mice. Climbing behavior was produced by similar doses of apomorphine and NPA (0.625-2.5 mg/kg s.c.), whereas NPA was 43 times more potent than apomorphine in inducing a hypothermic response. SKF38393 caused a shift to the left in the dose-response curve for NPA-induced climbing, the ED50 changing from 0.98 to 0.014 mg/kg. SKF38393 had no effect on apomorphine-induced climbing behaviour. The climbing response produced by apomorphine was antagonised by both D-1 and D-2 antagonists. Climbing behaviour induced by NPA (2.5 mg/kg) could be antagonised by SCH23390 but not by clebopride, however climbing behaviour induced by a low dose of NPA (0.06 mg/kg) plus SKF38393 could be blocked by both D-1 and D-2 receptor antagonists. The hypothermic responses produced by either apomorphine or NPA could only be reversed by the selective D-2 antagonist, clebopride. These results demonstrate that dopamine agonist-induced stereotyped cage climbing requires both D-1 and D-2 receptor stimulation, whereas the hypothermic response is D-2-mediated. The results also show that it is possible to assess the relative activity of a dopamine agonist at D-1 or D-2 receptors in vivo by comparing the ability of the compound to induce hypothermia and climbing behaviour. | lld:pubmed |
| pubmed-article:2184043 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2184043 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2184043 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2184043 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2184043 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2184043 | pubmed:author | pubmed-author:MooreN ANA | lld:pubmed |
| pubmed-article:2184043 | pubmed:author | pubmed-author:AxtonM SMS | lld:pubmed |
| pubmed-article:2184043 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2184043 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:2184043 | pubmed:volume | 178 | lld:pubmed |
| pubmed-article:2184043 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2184043 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2184043 | pubmed:pagination | 195-201 | lld:pubmed |
| pubmed-article:2184043 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2184043 | pubmed:meshHeading | pubmed-meshheading:2184043-... | lld:pubmed |
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| pubmed-article:2184043 | pubmed:meshHeading | pubmed-meshheading:2184043-... | lld:pubmed |
| pubmed-article:2184043 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2184043 | pubmed:articleTitle | The role of multiple dopamine receptors in apomorphine and N-n-propylnorapomorphine-induced climbing and hypothermia. | lld:pubmed |
| pubmed-article:2184043 | pubmed:affiliation | Lilly Research Centre, Eli Lilly and Co., Windlesham, Surrey U.K. | lld:pubmed |
| pubmed-article:2184043 | pubmed:publicationType | Journal Article | lld:pubmed |
