| pubmed-article:21802007 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21802007 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:21802007 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21802007 | lifeskim:mentions | umls-concept:C0376261 | lld:lifeskim |
| pubmed-article:21802007 | lifeskim:mentions | umls-concept:C1136254 | lld:lifeskim |
| pubmed-article:21802007 | lifeskim:mentions | umls-concept:C1568811 | lld:lifeskim |
| pubmed-article:21802007 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21802007 | pubmed:dateCreated | 2011-8-1 | lld:pubmed |
| pubmed-article:21802007 | pubmed:abstractText | Lantibiotics are ribosomally synthesized and posttranslationally modified antimicrobial peptides. The recently discovered lantibiotic epilancin 15X produced by Staphylococcus epidermidis 15X154 contains an unusual N-terminal lactate group. To understand its biosynthesis, the epilancin 15X biosynthetic gene cluster was identified. The N-terminal lactate is produced by dehydration of a serine residue in the first position of the core peptide by ElxB, followed by proteolytic removal of the leader peptide by ElxP and hydrolysis of the resulting new N-terminal dehydroalanine. The pyruvate group thus formed is reduced to lactate by an NADPH-dependent oxidoreductase designated ElxO. The enzymatic activity of ElxB, ElxP, and ElxO were investigated in vitro or in vivo and the importance of the N-terminal modification for peptide stability against bacterial aminopeptidases was assessed. | lld:pubmed |
| pubmed-article:21802007 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21802007 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21802007 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21802007 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21802007 | pubmed:issn | 1879-1301 | lld:pubmed |
| pubmed-article:21802007 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:21802007 | pubmed:author | pubmed-author:ZhangXingangX | lld:pubmed |
| pubmed-article:21802007 | pubmed:author | pubmed-author:VelásquezJuan... | lld:pubmed |
| pubmed-article:21802007 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21802007 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21802007 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:21802007 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:21802007 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21802007 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21802007 | pubmed:pagination | 857-67 | lld:pubmed |
| pubmed-article:21802007 | pubmed:meshHeading | pubmed-meshheading:21802007... | lld:pubmed |
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| pubmed-article:21802007 | pubmed:meshHeading | pubmed-meshheading:21802007... | lld:pubmed |
| pubmed-article:21802007 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21802007 | pubmed:articleTitle | Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate. | lld:pubmed |
| pubmed-article:21802007 | pubmed:affiliation | Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA. | lld:pubmed |
| pubmed-article:21802007 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21802007 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
