| pubmed-article:21801485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0013058 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0680730 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0298130 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C2350825 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C1148554 | lld:lifeskim |
| pubmed-article:21801485 | lifeskim:mentions | umls-concept:C1879938 | lld:lifeskim |
| pubmed-article:21801485 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21801485 | pubmed:dateCreated | 2011-8-1 | lld:pubmed |
| pubmed-article:21801485 | pubmed:abstractText | Reversed-phase high performance liquid chromatography (LC) method is developed for the assay of sodium montelukast in coated tables and its photodegradation kinetics. An isocratic LC separation is performed on a Zorbax XDB C18 column using a mobile phase of acetonitrile-methanol-water (pH 3.8) (75:10:15, v/v/v) at a flow rate of 0.8 mL/min and detection at 280 nm. The detector response for sodium montelukast is linear over the concentration range from 5-35 ?g/mL (r = 0.9999). The specificity of the method is proved using stress conditions. The solutions are exposed to UV radiation (352 nm), alkaline and acid hydrolysis, oxidation, and temperature (80 °C). The intra- and inter-day precision show suitable results (RSD < 0.49%). The accuracy of analytical method is 100.04% (RSD = 0.44%). Detection and quantification limits are 0.10 and 0.32 ?g/mL respectively. The robustness of the method is assured after small changes in chromatographic conditions. The kinetic of photodegradation using a LC method is established and it can be described by zero-order kinetics. This developed method show to be viable for the determination of sodium montelukast in pharmaceutical dosage form and satisfactory in the determination of the kinetics of degradation. | lld:pubmed |
| pubmed-article:21801485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21801485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21801485 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21801485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21801485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21801485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21801485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21801485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21801485 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21801485 | pubmed:issn | 1945-239X | lld:pubmed |
| pubmed-article:21801485 | pubmed:author | pubmed-author:SteppeMartinM | lld:pubmed |
| pubmed-article:21801485 | pubmed:author | pubmed-author:BreierAna RAR | lld:pubmed |
| pubmed-article:21801485 | pubmed:author | pubmed-author:RomanJulianaJ | lld:pubmed |
| pubmed-article:21801485 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21801485 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:21801485 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21801485 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21801485 | pubmed:pagination | 540-6 | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:meshHeading | pubmed-meshheading:21801485... | lld:pubmed |
| pubmed-article:21801485 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21801485 | pubmed:articleTitle | Stability indicating LC method to determination of sodium montelukast in pharmaceutical dosage form and its photodegradation kinetics. | lld:pubmed |
| pubmed-article:21801485 | pubmed:affiliation | Post-Graduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752. Lab. 402, Porto Alegre-RS CEP, 90610-000, Brazil. juli_roman@yahoo.com.br | lld:pubmed |
| pubmed-article:21801485 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21801485 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
