| pubmed-article:2178948 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2178948 | lifeskim:mentions | umls-concept:C0017462 | lld:lifeskim |
| pubmed-article:2178948 | lifeskim:mentions | umls-concept:C0020672 | lld:lifeskim |
| pubmed-article:2178948 | lifeskim:mentions | umls-concept:C0022816 | lld:lifeskim |
| pubmed-article:2178948 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:2178948 | lifeskim:mentions | umls-concept:C1546988 | lld:lifeskim |
| pubmed-article:2178948 | lifeskim:mentions | umls-concept:C0813872 | lld:lifeskim |
| pubmed-article:2178948 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2178948 | pubmed:dateCreated | 1990-4-26 | lld:pubmed |
| pubmed-article:2178948 | pubmed:abstractText | The broad spectrum excitatory amino acid antagonist, kynurenic acid was evaluated in a transient forebrain ischaemia model in gerbils. When administered i.p., 15 min prior to a 5 min period of ischaemia, a dose-related neuroprotective effect was seen with 800 mg/kg of kynurenic acid showing very good protection. A combination of kynurenic acid (200 or 400 mg/kg) and MK-801 (0.1 mg/kg) gave a synergistic neuroprotective effect. Neither kynurenic acid (200 or 400 mg/kg) nor MK-801 (0.3 mg/kg) was neuroprotective when administered by itself 30 min post-ischaemically, but when co-administered significant protection of the CA1 pyramidal neurones of the hippocampus was seen. In addition, we examined the effect of maintaining core body temperature on the neuroprotective action of MK-801 and kynurenic acid following the suggestion that it was a hypothermic effect of MK-801 which resulted in neuroprotection in gerbils. When the body temperature of the gerbils was maintained at 37 degrees C for a period of 24 h it did not affect the neuroprotective action of MK-801 (0.1 or 10 mg/kg) or kynurenic acid (200 mg/kg). | lld:pubmed |
| pubmed-article:2178948 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2178948 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2178948 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2178948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2178948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2178948 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2178948 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2178948 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2178948 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:2178948 | pubmed:author | pubmed-author:WoodruffG NGN | lld:pubmed |
| pubmed-article:2178948 | pubmed:author | pubmed-author:GillRR | lld:pubmed |
| pubmed-article:2178948 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2178948 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:2178948 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:2178948 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2178948 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2178948 | pubmed:pagination | 143-9 | lld:pubmed |
| pubmed-article:2178948 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:meshHeading | pubmed-meshheading:2178948-... | lld:pubmed |
| pubmed-article:2178948 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2178948 | pubmed:articleTitle | The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia. | lld:pubmed |
| pubmed-article:2178948 | pubmed:affiliation | Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, U.K. | lld:pubmed |
| pubmed-article:2178948 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2178948 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2178948 | lld:pubmed |
