| pubmed-article:21784893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21784893 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:21784893 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:21784893 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21784893 | pubmed:dateCreated | 2011-8-1 | lld:pubmed |
| pubmed-article:21784893 | pubmed:abstractText | HIVAN1, HIVAN2, and HIVAN3 are nephropathy-susceptibility loci previously identified in the HIV-1 transgenic mouse, a model of collapsing glomerulopathy. The HIVAN1 and HIVAN2 loci modulate expression of Nphs2, which encodes podocin and several other podocyte-expressed genes. To identify additional loci predisposing to nephropathy, we performed a genome-wide scan in 165 backcross mice generated between the nephropathy-sensitive HIV-1-transgenic FVB/NJ (TgFVB) strain and the resistant Balb/cJ (BALB) strain. We identified a major susceptibility locus (HIVAN4) on chromosome 6 G3-F3, with BALB alleles conferring a twofold reduction in severity (peak LOD score = 4.0). Similar to HIVAN1 and HIVAN2, HIVAN4 modulated expression of Nphs2, indicating a common pathway underlying these loci. We independently confirmed the HIVAN4 locus in a sister TgFVB colony that experienced a dramatic loss of nephropathy subsequent to a breeding bottleneck. In this low-penetrance line, 3% of the genome was admixed with BALB alleles, suggesting a remote contamination event. The admixture localized to discrete segments on chromosome 2 and at the HIVAN4 locus. HIVAN4 candidate genes include killer lectin-like receptor genes as well as A2m and Ptpro, whose gene products are enriched in the glomerulus and interact with HIV-1 proteins. In summary, these data identify HIVAN4 as a major quantitative trait locus for nephropathy and a transregulator of Nphs2. Furthermore, similar selective breeding strategies may help identify further susceptibility loci. | lld:pubmed |
| pubmed-article:21784893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21784893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21784893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21784893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21784893 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:21784893 | pubmed:issn | 1533-3450 | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:BruggemanLesl... | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:SedorJohn RJR | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:D'AgatiVivett... | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:ThomasRobert... | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:GharaviAli... | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:WuZhenzhenZ | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:ZhengZongyuZ | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:PapetaNatalia... | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:SterkenRoelR | lld:pubmed |
| pubmed-article:21784893 | pubmed:author | pubmed-author:PrakashSindhu... | lld:pubmed |
| pubmed-article:21784893 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21784893 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:21784893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21784893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21784893 | pubmed:pagination | 1497-504 | lld:pubmed |
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| pubmed-article:21784893 | pubmed:meshHeading | pubmed-meshheading:21784893... | lld:pubmed |
| pubmed-article:21784893 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21784893 | pubmed:articleTitle | Identification of the nephropathy-susceptibility locus HIVAN4. | lld:pubmed |
| pubmed-article:21784893 | pubmed:affiliation | Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:21784893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21784893 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
