| pubmed-article:2177604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0009452 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0061928 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0110613 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:2177604 | lifeskim:mentions | umls-concept:C0205144 | lld:lifeskim |
| pubmed-article:2177604 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2177604 | pubmed:dateCreated | 1991-3-13 | lld:pubmed |
| pubmed-article:2177604 | pubmed:abstractText | Natural and synthetic retinoids are potent inhibitors of experimental carcinogenesis in animals and cause reversion of premalignant lesions in humans. In the model C3H 10T1/2 cell system, retinoids enhance postconfluent growth control, reversibly inhibit carcinogen-induced transformation, and enhance gap junctional intercellular communication. These effects are highly correlated. 10T1/2 cells were found to express low levels of connexin 43, a gap junctional protein first found in the heart. After treatment of confluent 10T1/2 cells with the synthetic retinoid tetrahydrotetramethylnapthalenylpropenylbenzoic acid (TTNPB), levels of connexin 43 mRNA and protein increased within 6 h of treatment, while elevation of junctional communication was detected within 12-18 h. The maximally effective concentration of TTNPB (10(-8) M) caused an approximate 10-fold elevation of connexin 43 gene transcripts after 72 h. Indirect immunofluorescence microscopy using a polyclonal antibody to the synthetic C-terminal region of connexin 43 demonstrated that TTNPB induced many fluorescent plaques in regions of cell-cell contact. These results provide a molecular basis for the retinoid-enhanced junctional communication in 10T1/2 cells. It is proposed that one action of retinoids is to modulate the intercellular transfer of signal molecules. These could mediate many of the physiological actions of retinoids on growth control and carcinogenesis. | lld:pubmed |
| pubmed-article:2177604 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2177604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2177604 | pubmed:issn | 0899-1987 | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:BertramJ SJS | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:RogersMM | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:BeresteckyJ... | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:NicholsonB... | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:HossainM ZMZ | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:KadleRR | lld:pubmed |
| pubmed-article:2177604 | pubmed:author | pubmed-author:YUHH | lld:pubmed |
| pubmed-article:2177604 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2177604 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:2177604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2177604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2177604 | pubmed:pagination | 335-43 | lld:pubmed |
| pubmed-article:2177604 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:meshHeading | pubmed-meshheading:2177604-... | lld:pubmed |
| pubmed-article:2177604 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2177604 | pubmed:articleTitle | Retinoid-enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein. | lld:pubmed |
| pubmed-article:2177604 | pubmed:affiliation | Basic Science Program, University of Hawaii, Honolulu 96813. | lld:pubmed |
| pubmed-article:2177604 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2177604 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2177604 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2177604 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2177604 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2177604 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2177604 | lld:pubmed |
