| pubmed-article:21775604 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C1417026 | lld:lifeskim |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C0598952 | lld:lifeskim |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:21775604 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:21775604 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:21775604 | pubmed:dateCreated | 2011-7-21 | lld:pubmed |
| pubmed-article:21775604 | pubmed:abstractText | Brain-derived neurotrophic factor (BDNF), secreted from target tissues, binds and activates TrkB receptors, located on axonal terminals of the innervating neurons, and thereby initiates retrograde signaling. Long-range anterograde transport of TrkB in axons and dendrites requires kinesin-mediated transport. However, it remains unknown whether anterograde TrkB transport mechanisms are the same in axons versus in dendrites. Here, we show that c-Jun NH(2)-terminal kinase-interacting protein 3 (JIP3) binds directly to TrkB, via a minimal 12 aa domain in the TrkB juxtamembrane region, and links TrkB to kinesin-1. The JIP3/TrkB interaction selectively drives TrkB anterograde transport in axons but not in dendrites of rat hippocampal neurons. Moreover, we find that TrkB axonal transport mediated by JIP3 could regulate BDNF-induced Erk activation and axonal filopodia formation. Our findings demonstrate a role for JIP3-mediated TrkB anterograde axonal transport in recruiting more TrkB into distal axons and facilitating BDNF-induced retrograde signaling and synapse modulation, which provides a novel mechanism of how the TrkB anterograde transport can be coupled to BDNF signaling in distal axons. | lld:pubmed |
| pubmed-article:21775604 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21775604 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21775604 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21775604 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21775604 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:ZhaoLingL | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:WangJueJ | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:SunTaoT | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:ChenZhe-YuZY | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:YanJingJ | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:DuanShanS | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:GengZhaoZ | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:SunHai-JiHJ | lld:pubmed |
| pubmed-article:21775604 | pubmed:author | pubmed-author:HuangShu-Hong... | lld:pubmed |
| pubmed-article:21775604 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21775604 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:21775604 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:21775604 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21775604 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21775604 | pubmed:pagination | 10602-14 | lld:pubmed |
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| pubmed-article:21775604 | pubmed:meshHeading | pubmed-meshheading:21775604... | lld:pubmed |
| pubmed-article:21775604 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21775604 | pubmed:articleTitle | JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. | lld:pubmed |
| pubmed-article:21775604 | pubmed:affiliation | Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, People's Republic of China. | lld:pubmed |
| pubmed-article:21775604 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21775604 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:23162 | entrezgene:pubmed | pubmed-article:21775604 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21775604 | lld:entrezgene |
