| pubmed-article:2177478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C0439660 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C0040132 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:2177478 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:2177478 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:2177478 | pubmed:dateCreated | 1991-3-1 | lld:pubmed |
| pubmed-article:2177478 | pubmed:abstractText | Thyroid stimulating hormone (TSH) and insulin-like growth factors type 1 (IGF-I) regulate the proliferation and differentiation of cultured thyroid cells but not of cultured liver cells. We have examined the influence of TSH and IGF-I on the metabolic functions and proliferation of somatic hybrids obtained by fusing rat thyroid cells (FRTL5) with rat liver cells (BRL). While IGF-I is able to stimulate the proliferation of the hybrid cells (TxL) TSH fails to induce their growth. However, the hybrid TxL cells have surface TSH receptors with normal ligand characteristics. The addition of TSH to TxL cells led to typical enhancement of cAMP production and depolymerization of actin filaments. Yet, TSH failed to stimulate iodine uptake in the hybrid cells. Interestingly, iodine inhibited TxL proliferation induced by IGF-I but not by serum. It is concluded that the hybrid TxL cells inherited from the parental thyroid cells several important differentiated traits including mitogenic pathways induced and used by IGF-I, functional TSH receptors, and sensitivity to the inhibitory action of iodine. | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2177478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2177478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2177478 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2177478 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:2177478 | pubmed:author | pubmed-author:GarbeGG | lld:pubmed |
| pubmed-article:2177478 | pubmed:author | pubmed-author:Di CarloAA | lld:pubmed |
| pubmed-article:2177478 | pubmed:author | pubmed-author:TramontanoDD | lld:pubmed |
| pubmed-article:2177478 | pubmed:author | pubmed-author:RomaniLL | lld:pubmed |
| pubmed-article:2177478 | pubmed:author | pubmed-author:VenezianiB... | lld:pubmed |
| pubmed-article:2177478 | pubmed:author | pubmed-author:VilloneGG | lld:pubmed |
| pubmed-article:2177478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2177478 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:2177478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2177478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2177478 | pubmed:pagination | 2703-11 | lld:pubmed |
| pubmed-article:2177478 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:meshHeading | pubmed-meshheading:2177478-... | lld:pubmed |
| pubmed-article:2177478 | pubmed:year | 1990 | lld:pubmed |
