| pubmed-article:21773002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21773002 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:21773002 | lifeskim:mentions | umls-concept:C1305855 | lld:lifeskim |
| pubmed-article:21773002 | lifeskim:mentions | umls-concept:C0342548 | lld:lifeskim |
| pubmed-article:21773002 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:21773002 | pubmed:dateCreated | 2011-7-20 | lld:pubmed |
| pubmed-article:21773002 | pubmed:abstractText | To infer the causal association between childhood BMI and age at menarche, we performed a mendelian randomisation analysis using twelve established "BMI-increasing" genetic variants as an instrumental variable (IV) for higher BMI. In 8,156 women of European descent from the EPIC-Norfolk cohort, height was measured at age 39-77 years; age at menarche was self-recalled, as was body weight at age 20 years, and BMI at 20 was calculated as a proxy for childhood BMI. DNA was genotyped for twelve BMI-associated common variants (in/near FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, MTCH2, SEC16B, FAIM2 and SH2B1), and for each individual a "BMI-increasing-allele-score" was calculated by summing the number of BMI-increasing alleles across all 12 loci. Using this BMI-increasing-allele-score as an instrumental variable for BMI, each 1?kg/m(2) increase in childhood BMI was predicted to result in a 6.5% (95% CI: 4.6-8.5%) higher absolute risk of early menarche (before age 12 years). While mendelian randomisation analysis is dependent on a number of assumptions, our findings support a causal effect of BMI on early menarche and suggests that increasing prevalence of childhood obesity will lead to similar trends in the prevalence of early menarche. | lld:pubmed |
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| pubmed-article:21773002 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21773002 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21773002 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:21773002 | pubmed:issn | 2090-0716 | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:WarehamNichol... | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:LoosRuth J... | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:OngKen KKK | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:KhawKay-TeeKT | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:XuShengliS | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:LubenRobert... | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:ElksCathy ECE | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:SharpStephen... | lld:pubmed |
| pubmed-article:21773002 | pubmed:author | pubmed-author:MumbyHannah... | lld:pubmed |
| pubmed-article:21773002 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21773002 | pubmed:volume | 2011 | lld:pubmed |
| pubmed-article:21773002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21773002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21773002 | pubmed:pagination | 180729 | lld:pubmed |
| pubmed-article:21773002 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21773002 | pubmed:articleTitle | Mendelian Randomisation Study of Childhood BMI and Early Menarche. | lld:pubmed |
| pubmed-article:21773002 | pubmed:affiliation | MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285, Cambridge CB2 0QQ, UK. | lld:pubmed |
| pubmed-article:21773002 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:132789 | entrezgene:pubmed | pubmed-article:21773002 | lld:entrezgene |
