| pubmed-article:21765602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C2711227 | lld:lifeskim |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C0009830 | lld:lifeskim |
| pubmed-article:21765602 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:21765602 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21765602 | pubmed:dateCreated | 2011-7-18 | lld:pubmed |
| pubmed-article:21765602 | pubmed:abstractText | p59fyn, a protein tyrosine kinase belonging to the src-family, is involved in the regulatory mechanism of acute response to ethanol in the central nervous system. A previous report showed an association between src-family kinase activity and fatty acid oxidation, and it also reported that hepatic free fatty acid levels were low in Fyn-/- mice. We examined, using Fyn-/- mice whether Fyn is also involved in fatty acid metabolism and the development of pathological changes in the liver in response to chronic ethanol consumption. C57BL/6J Fyn-/- and Fyn+/+ mice were fed for 8 weeks with either a liquid diet comprising ethanol or one in which the calories from ethanol were replaced with carbohydrates. Chronic ethanol consumption for 8 weeks resulted in remarkable hepatic steatosis in Fyn+/+ mice but not in Fyn-/- mice. Chronic ethanol consumption induced a significant decrease in hepatic FFA and triglyceride levels in Fyn-/- mice. Levels of interleukin-6, which is associated with the enhancement of fatty acid oxidation, was also increased significantly in the livers of ethanol-fed Fyn-/- mice. The results suggest that Fyn is involved in the enhancement of fatty acid oxidation and the development of hepatic steatosis caused by chronic ethanol consumption. | lld:pubmed |
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| pubmed-article:21765602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21765602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21765602 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:21765602 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21765602 | pubmed:issn | 1880-5086 | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:FukudaAkiraA | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:HiguchiKazuhi... | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:MiyajiKatsuhi... | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:FukuiHideoH | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:FukunishiShin... | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:TsudaYasuhiro... | lld:pubmed |
| pubmed-article:21765602 | pubmed:author | pubmed-author:TakeshitaAtsu... | lld:pubmed |
| pubmed-article:21765602 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21765602 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:21765602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21765602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21765602 | pubmed:pagination | 20-4 | lld:pubmed |
| pubmed-article:21765602 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21765602 | pubmed:articleTitle | p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption. | lld:pubmed |
| pubmed-article:21765602 | pubmed:affiliation | Department of Gastroenteroloy and Hepatology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. | lld:pubmed |
| pubmed-article:21765602 | pubmed:publicationType | Journal Article | lld:pubmed |
