| pubmed-article:2176140 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C0010825 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C0237401 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C1979893 | lld:lifeskim |
| pubmed-article:2176140 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:2176140 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2176140 | pubmed:dateCreated | 1991-2-14 | lld:pubmed |
| pubmed-article:2176140 | pubmed:abstractText | In order to delineate the molecular pathogenesis of the increased susceptibility to CMV disease in HIV infection, the patterns of antigen responsiveness in HIV-infected and non-infected individuals were investigated. CMV was fractionated by SDS-PAGE and electroblotted onto nitrocellulose. Lymphoproliferative responses of healthy HIV-, CMV+ individuals and HIV+, CMV+ asymptomatic patients to a whole CMV antigen preparation and to 20 fractions of nitrocellulose-bound CMV were then compared. Three fractions of approximate molecular weight of 130-165, 65-75, and 55-65 kD appeared to contain the major T cell stimulating antigens for HIV-, CMV+ individuals. A statistically significant depression of responses to fractions containing antigens in the ranges of 130-165 kD and 55-65 kD but not to whole CMV was seen in HIV+ individuals compared with controls. In healthy controls, the sum of the proliferative responses as measured by 3H-thymidine uptake to these three major fractions was approximately equal to the response to a whole CMV antigen preparation, whereas it was less than half of this response in five out of six HIV+ subjects. When antibody activities to CMV antigens were analysed by immunoblotting of sera from the two subject groups and also sera of ARC and AIDS patients, a selective loss of reactivity was revealed in 10 out of 19 HIV+ subjects to a band of 26-28 kD whereas all 15 HIV-, CMV+ controls recognized this band. Serum IgG and IgM values were both significantly higher in HIV+ individuals than in controls. These findings suggest that specific lesions in the repertoire of immune responsiveness to CMV antigens occur in HIV+ individuals. | lld:pubmed |
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| pubmed-article:2176140 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2176140 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2176140 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2176140 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2176140 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2176140 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:2176140 | pubmed:author | pubmed-author:StrannegårdOO | lld:pubmed |
| pubmed-article:2176140 | pubmed:author | pubmed-author:ConverseP JPJ | lld:pubmed |
| pubmed-article:2176140 | pubmed:author | pubmed-author:BrittonSS | lld:pubmed |
| pubmed-article:2176140 | pubmed:author | pubmed-author:EhrnstAA | lld:pubmed |
| pubmed-article:2176140 | pubmed:author | pubmed-author:FehnigerT ETE | lld:pubmed |
| pubmed-article:2176140 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2176140 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2176140 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2176140 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2176140 | pubmed:pagination | 559-66 | lld:pubmed |
| pubmed-article:2176140 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2176140 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2176140 | pubmed:articleTitle | Immune responses to fractionated cytomegalovirus (CMV) antigens after HIV infection. Loss of cellular and humoral reactivity to antigens recognized by HIV-, CMV+ individuals. | lld:pubmed |
| pubmed-article:2176140 | pubmed:affiliation | Department of Infectious Diseases, Roslagstull Hospital, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:2176140 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2176140 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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