| pubmed-article:21760811 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C0021278 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C0004886 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C0750540 | lld:lifeskim |
| pubmed-article:21760811 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:21760811 | pubmed:dateCreated | 2011-7-15 | lld:pubmed |
| pubmed-article:21760811 | pubmed:abstractText | A number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African females and males may have their lives saved each year by the nonspecific immunological benefits of Bacillus Calmette-Guerin (BCG) vaccination. From an immunological point of view, we hypothesise that the adverse effects of DTwP vaccine may occur because of the Th2-polarising effect of the aluminium phosphate adjuvant in the vaccine and because intramuscular administration of the vaccine may cause chronic inflammation at the site of injection. However, the Th1-polarising effect of BCG is likely to be beneficial. Sexual dimorphism affecting immune functions and vitamin A supplementation may influence both the deleterious and beneficial nonspecific effects of immunisation. | lld:pubmed |
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| pubmed-article:21760811 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21760811 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21760811 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:21760811 | pubmed:issn | 1687-9694 | lld:pubmed |
| pubmed-article:21760811 | pubmed:author | pubmed-author:ClaessonMogen... | lld:pubmed |
| pubmed-article:21760811 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21760811 | pubmed:volume | 2011 | lld:pubmed |
| pubmed-article:21760811 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21760811 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21760811 | pubmed:pagination | 706304 | lld:pubmed |
| pubmed-article:21760811 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21760811 | pubmed:articleTitle | Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality. | lld:pubmed |
| pubmed-article:21760811 | pubmed:affiliation | Laboratory for Experimental and Cellular Immunology, Department of International Health, Immunology and Microbiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:21760811 | pubmed:publicationType | Journal Article | lld:pubmed |
