Linked Life Data

21751159

Source:http://linkedlifedata.com/resource/pubmed/id/21751159

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SubjectPredicateObjectContext
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pubmed-article:21751159pubmed:abstractTextHuman leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4(+) T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-DRB alleles and the sequences of the HLA-DRB promoter region in 97 unrelated patients with pulmonary tuberculosis and in 62 unrelated normal controls of the Han nationality from North China, using PCR with sequence-specific primers and PCR direct sequencing. We found that the frequency of HLA-DRB1*15 was significantly higher in the pulmonary tuberculosis group than in the healthy control group. The P value was 0.001, and the odds ratio was 3.793. The pulmonary tuberculosis group had the same HLA-DRB1 promoter region sequences as the control group. We concluded that the HLA-DRB1*15 allele is associated with pulmonary tuberculosis in the Han nationality from North China. The HLA-DRB1 promoter region sequences had no association with the development of pulmonary tuberculosis.lld:pubmed
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pubmed-article:21751159pubmed:authorpubmed-author:YangLLlld:pubmed
pubmed-article:21751159pubmed:authorpubmed-author:HuX LXLlld:pubmed
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pubmed-article:21751159pubmed:pagination1331-6lld:pubmed
pubmed-article:21751159pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:21751159pubmed:year2011lld:pubmed
pubmed-article:21751159pubmed:articleTitleAssociation of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients.lld:pubmed
pubmed-article:21751159pubmed:affiliationDepartment of Clinical Immunology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, P.R. China. shiguangli878@sina.comlld:pubmed
pubmed-article:21751159pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21751159pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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