| pubmed-article:21741601 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21741601 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:21741601 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:21741601 | lifeskim:mentions | umls-concept:C0034786 | lld:lifeskim |
| pubmed-article:21741601 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:21741601 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21741601 | pubmed:dateCreated | 2011-7-11 | lld:pubmed |
| pubmed-article:21741601 | pubmed:abstractText | Endocrine therapies for breast cancer that target the estrogen receptor (ER) are ineffective in the 25%-30% of cases that are ER negative (ER-). Androgen receptor (AR) is expressed in 60%-70% of breast tumors, independent of ER status. How androgens and AR regulate breast cancer growth remains largely unknown. We find that AR is enriched in ER- breast tumors that overexpress HER2. Through analysis of the AR cistrome and androgen-regulated gene expression in ER-/HER2+ breast cancers we find that AR mediates ligand-dependent activation of Wnt and HER2 signaling pathways through direct transcriptional induction of WNT7B and HER3. Specific targeting of AR, Wnt or HER2 signaling impairs androgen-stimulated tumor cell growth suggesting potential therapeutic approaches for ER-/HER2+ breast cancers. | lld:pubmed |
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| pubmed-article:21741601 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:21741601 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21741601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21741601 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21741601 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21741601 | pubmed:issn | 1878-3686 | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:BrownMylesM | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:RimmDavid LDL | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:LiuX... | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:ImaiYuukiY | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:NiMinM | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:BaileyShannon... | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:ChenYiwenY | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:LimElgeneE | lld:pubmed |
| pubmed-article:21741601 | pubmed:author | pubmed-author:WimberlyHalli... | lld:pubmed |
| pubmed-article:21741601 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21741601 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21741601 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:21741601 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:21741601 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21741601 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21741601 | pubmed:pagination | 119-31 | lld:pubmed |
| pubmed-article:21741601 | pubmed:dateRevised | 2011-9-30 | lld:pubmed |
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| pubmed-article:21741601 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21741601 | pubmed:articleTitle | Targeting androgen receptor in estrogen receptor-negative breast cancer. | lld:pubmed |
| pubmed-article:21741601 | pubmed:affiliation | Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. | lld:pubmed |
| pubmed-article:21741601 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21741601 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:21741601 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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