| pubmed-article:2174102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2174102 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2174102 | lifeskim:mentions | umls-concept:C1364508 | lld:lifeskim |
| pubmed-article:2174102 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:2174102 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:2174102 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:2174102 | lifeskim:mentions | umls-concept:C0582520 | lld:lifeskim |
| pubmed-article:2174102 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2174102 | pubmed:dateCreated | 1991-1-8 | lld:pubmed |
| pubmed-article:2174102 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:abstractText | A 6.3-kbp segment of DNA, upstream of the human thyroid peroxidase gene, and various deletions thereof were linked to a promoterless bacterial chloramphenicol acetyltransferase reporter gene. These constructs were analyzed by transfection and expression in rat FRTL-5 thyroid cells and in human hepatoma HepG2 cells to localize sequences that are important for thyroid cell-specific expression of the thyroid peroxidase gene. A thyroid-specific enhancer element, capable of activating enhancerless simian virus 40 promoter expression in FRTL-5 cells, was localized to a 230-bp region approximately 5.5 kbp upstream of the human thyroid peroxidase gene transcription start site. DNase I footprinting, using nuclear extracts prepared from FRTL-5 cells, revealed three regions within the 230-bp fragment; none of these regions were protected by nuclear extracts from HepG2 cells. Gel mobility shift assays, using double-stranded oligonucleotides corresponding to the three protected regions, further confirmed the existence of factors in FRTL-5 cells, but not HepG2 cells, able to specifically bind to the enhancer sequences. These results suggest the presence of three cis-acting DNA elements in the human thyroid peroxidase gene enhancer that interact with thyroid-specific trans-acting factors. | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2174102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2174102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2174102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2174102 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2174102 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2174102 | pubmed:author | pubmed-author:KimuraSS | lld:pubmed |
| pubmed-article:2174102 | pubmed:author | pubmed-author:KikkawaFF | lld:pubmed |
| pubmed-article:2174102 | pubmed:author | pubmed-author:GonzalezF JFJ | lld:pubmed |
| pubmed-article:2174102 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2174102 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2174102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2174102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2174102 | pubmed:pagination | 6216-24 | lld:pubmed |
| pubmed-article:2174102 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:meshHeading | pubmed-meshheading:2174102-... | lld:pubmed |
| pubmed-article:2174102 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2174102 | pubmed:articleTitle | Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene. | lld:pubmed |
| pubmed-article:2174102 | pubmed:affiliation | Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:2174102 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2174102 | lld:pubmed |
