| pubmed-article:2173760 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0027410 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0574032 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0081295 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0599473 | lld:lifeskim |
| pubmed-article:2173760 | lifeskim:mentions | umls-concept:C0205254 | lld:lifeskim |
| pubmed-article:2173760 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2173760 | pubmed:dateCreated | 1990-12-31 | lld:pubmed |
| pubmed-article:2173760 | pubmed:abstractText | The opiate antagonist (-)-cyclofoxy [(-)-CF] and the receptor inert enantiomer (+)-CF were radiolabeled with 18F or 3H and administered to conscious Sprague-Dawley rats; an isotope effect was not observed. Constant i.v. infusion of both 18F-(-)-CF and 3H-(+)-CF in tracer amounts showed a marked difference in the tissue level of 18F-(-)-CF among various brain structures, whereas the values for 3H-(+)-CF were lower and much less variable. Co-infusion of unlabeled (-)-CF (1 mg/rat) did not change the tissue binding of 3H-(+)-CF in any brain structure, but reduced that of 18F-(-)-CF to the same level as 3H-(+)-CF. These results demonstrate an identical nonspecific tissue binding for (+)- and (-)-CF in vivo, and suggest that (+)-CF can be used to measure the "nonspecific" component of (-)-CF binding in brain. A nonlinear analysis of the 3H-(+)-CF data indicated the presence of both "instantaneous" and time-dependent components in nonspecific tissue binding and that nonspecific binding varied 1.5-fold in different brain structures. The combined 3H-(+)-CF and 18F-(-)-CF data were fitted to a four-compartment model, which includes parameters for capillary transport, "instantaneous" and time-dependent nonspecific tissue binding, as well as receptor association and dissociation. The receptor-association rate constant varied considerably in various structures of cerebrum (2.0-8.7 min-1), whereas receptor dissociation was estimated within a narrow range (0.12-0.17 min-1). The receptor binding potential (receptor association/dissociation) ranged between 12.7 and 56.2 and was in good agreement with previous estimates in vitro. | lld:pubmed |
| pubmed-article:2173760 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2173760 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2173760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2173760 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2173760 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2173760 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:SawadaYY | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:RiceK CKC | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:KawaiRR | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:BlasbergR GRG | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:DunnBB | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:NewmanA HAH | lld:pubmed |
| pubmed-article:2173760 | pubmed:author | pubmed-author:ChanningMM | lld:pubmed |
| pubmed-article:2173760 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2173760 | pubmed:volume | 255 | lld:pubmed |
| pubmed-article:2173760 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2173760 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2173760 | pubmed:pagination | 826-35 | lld:pubmed |
| pubmed-article:2173760 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:meshHeading | pubmed-meshheading:2173760-... | lld:pubmed |
| pubmed-article:2173760 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2173760 | pubmed:articleTitle | Kinetic analysis of the opiate antagonist cyclofoxy in rat brain: simultaneous infusion of active and inactive enantiomers. | lld:pubmed |
| pubmed-article:2173760 | pubmed:affiliation | Nuclear Medicine Department, National Institutes of Health, Bethesda, Maryland. | lld:pubmed |
| pubmed-article:2173760 | pubmed:publicationType | Journal Article | lld:pubmed |
