| pubmed-article:2172521 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0086949 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0035316 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0061465 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0549255 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2172521 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:2172521 | pubmed:dateCreated | 1990-12-19 | lld:pubmed |
| pubmed-article:2172521 | pubmed:abstractText | 1. Cells in the ganglion cell layer of salamander retinal slices were voltage clamped using patch pipettes. Light elicited transient excitatory postsynaptic currents (EPSCs) in on-off ganglion cells and sustained EPSCs in on ganglion cells. Light-evoked inhibitory postsynaptic currents in these cells could be blocked by 100 microM-bicuculline methobromide and 500 nM-strychnine. 2. In the presence of external Cd2+, at a concentration that blocked light-evoked synaptic inputs, N-methyl-D-aspartate (NMDA) and the non-NMDA-receptor agonists, quisqualate and kainate, gated conductances in both on-off and on ganglion cells. The current-voltage (I-V) curve for the conductance elicited by NMDA had a negative slope between -40 and -70 mV and a reversal potential near 0 mV. The I-V curves for the non-NMDA-receptor-mediated conductances were nearly linear and also had reversal potentials near 0 mV. 3. I-V curves were measured at an early time point near the peak of transient EPSCs and at a later time point during the decay phase of the responses. The late I-V curve had a negative slope below -40 mV. The early I-V curve had a positive slope over the entire voltage range but the slope was greater at positive than at negative potentials. The evoked current reversed near 0 mV at both time points. 4. The region of negative slope of the late I-V curve was eliminated when Mg2+ was removed from the external saline. A slowly decaying component of transient EPSCs was eliminated in 20 microM-DL-2-amino-7-phosphonoheptanoate (AP7), an NMDA-receptor antagonist. 5. Application of 1 microM-6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-NMDA-receptor antagonist at this concentration, blocked a fast component of transient EPSCs. 6. Our results demonstrate that the synaptic inputs to on-off ganglion cells have two components: a slower NMDA-receptor-mediated component having a time-to-peak of 110 +/- 45 ms and an e-fold decay time of 209 +/- 35 ms at -31 mV (mean +/- S.D., n = 5), and a faster non-NMDA-receptor-mediated component having a time-to-peak of 28 +/- 10 ms and an e-fold decay time of 43 +/- 20 ms at -31 mV (n = 8). 7. A similar analysis of sustained EPSCs of on ganglion cells showed that these currents resulted from sustained activation of both NMDA and non-NMDA receptors. | lld:pubmed |
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| pubmed-article:2172521 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2172521 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2172521 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2172521 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:2172521 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:2172521 | pubmed:author | pubmed-author:CopenhagenD... | lld:pubmed |
| pubmed-article:2172521 | pubmed:author | pubmed-author:TaylorW RWR | lld:pubmed |
| pubmed-article:2172521 | pubmed:author | pubmed-author:MittmanSS | lld:pubmed |
| pubmed-article:2172521 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2172521 | pubmed:volume | 428 | lld:pubmed |
| pubmed-article:2172521 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2172521 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2172521 | pubmed:pagination | 175-97 | lld:pubmed |
| pubmed-article:2172521 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2172521 | pubmed:meshHeading | pubmed-meshheading:2172521-... | lld:pubmed |
| pubmed-article:2172521 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2172521 | pubmed:articleTitle | Concomitant activation of two types of glutamate receptor mediates excitation of salamander retinal ganglion cells. | lld:pubmed |
| pubmed-article:2172521 | pubmed:affiliation | Department of Ophthalmology, University of California, San Francisco 94143. | lld:pubmed |
| pubmed-article:2172521 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2172521 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2172521 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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