| pubmed-article:21725055 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0002871 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0919490 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C1706474 | lld:lifeskim |
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| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C1522496 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0014819 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C1711300 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0376558 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C2700613 | lld:lifeskim |
| pubmed-article:21725055 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:21725055 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:21725055 | pubmed:dateCreated | 2011-9-2 | lld:pubmed |
| pubmed-article:21725055 | pubmed:abstractText | Anemia of chronic disease is a complication accompanying many inflammatory diseases. The proinflammatory cytokine IFN-? has been implicated in this form of anemia, but the underlying mechanism remains unclear. Here we describe a novel mouse model for anemia of chronic disease, in which enhanced CD27-mediated costimulation strongly increases the formation of IFN-?-producing effector T cells, leading to a progressive anemia. We demonstrate that the anemia in these mice is fully dependent on IFN-? and that this cytokine reduces both the life span and the formation of red blood cells. Molecular analysis revealed that IFN-? induces expression of the transcription factors of interferon regulatory factor-1 (IRF-1) and PU.1 in both murine and human erythroid precursors. We found that, on IFN-? stimulation, IRF-1 binds to the promoter of SPI.1 (PU.1) and induces PU.1 expression, leading to inhibition of erythropoiesis. Notably, down-regulation of either IRF-1 or PU.1 expression is sufficient to overcome IFN-?-induced inhibition of erythropoiesis. These findings reveal a molecular mechanism by which chronic exposure to IFN-? induces anemia. | lld:pubmed |
| pubmed-article:21725055 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21725055 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21725055 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21725055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21725055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21725055 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21725055 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21725055 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21725055 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:Salat... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:GutiérrezLaur... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:PhilipsenSjaa... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:PapadopoulosP... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:WensveenFelix... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:OzgürZelihaZ | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:21725055 | pubmed:author | pubmed-author:LibregtsSten... | lld:pubmed |
| pubmed-article:21725055 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21725055 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21725055 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:21725055 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21725055 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21725055 | pubmed:pagination | 2578-88 | lld:pubmed |
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| pubmed-article:21725055 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21725055 | pubmed:articleTitle | Chronic IFN-? production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis. | lld:pubmed |
| pubmed-article:21725055 | pubmed:affiliation | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:21725055 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21725055 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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