| pubmed-article:21723156 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C1420799 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C1326120 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C1819992 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:21723156 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:21723156 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21723156 | pubmed:dateCreated | 2011-7-22 | lld:pubmed |
| pubmed-article:21723156 | pubmed:abstractText | Dendritic cells (DCs) regulate both immunity and tolerance. Here we have shown that the ubiquitin editing enzyme A20 (Tnfaip3) determines the activation threshold of DCs, via control of canonical NF-?B activation. Tnfaip3(fl/fl)Cd11c-cre(+) mice lacking A20 in DCs demonstrated spontaneous proliferation of conventional and double-negative T cells, their conversion to interferon-? (IFN-?)-producing effector cells, and expansion of plasma cells. They developed ds-DNA antibodies, nephritis, the antiphospholipid syndrome, and lymphosplenomegaly-features of systemic lupus erythematosus-and extramedullary hematopoiesis. A20-deficient DCs were resistant to apoptosis, caused by increased sensitivity to CD40L and RANKL prosurvival signals and upregulation of antiapoptotic proteins Bcl-2 and Bcl-x. They captured injected apoptotic cells more efficiently, resisted the inhibitory effects of apoptotic cells, and induced self-reactive effector lymphocytes. Because genetic polymorphisms in TNFAIP3 are associated with human autoimmune disorders, these findings identify A20-mediated control of DC activation as a crucial checkpoint in the development of systemic autoimmunity. | lld:pubmed |
| pubmed-article:21723156 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21723156 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21723156 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21723156 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21723156 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:ReizisBorisB | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:BeyaertRudiR | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:JanssensSophi... | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:WaelputWimW | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:KoolMirjamM | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:LambrechtBart... | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:HammadHamidaH | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:ElewautDirkD | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:van LooGeertG | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:MuskensFemkeF | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:SzeMozesM | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:Branco-Madeir... | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:21723156 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:21723156 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21723156 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21723156 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:21723156 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:21723156 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21723156 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21723156 | pubmed:pagination | 82-96 | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
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| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
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| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:meshHeading | pubmed-meshheading:21723156... | lld:pubmed |
| pubmed-article:21723156 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21723156 | pubmed:articleTitle | The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. | lld:pubmed |
| pubmed-article:21723156 | pubmed:affiliation | Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Gent, 9000 Gent, Belgium. | lld:pubmed |
| pubmed-article:21723156 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21723156 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21723156 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:21929 | entrezgene:pubmed | pubmed-article:21723156 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21723156 | lld:entrezgene |
