| pubmed-article:2170445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0699493 | lld:lifeskim |
| pubmed-article:2170445 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:2170445 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2170445 | pubmed:dateCreated | 1990-11-21 | lld:pubmed |
| pubmed-article:2170445 | pubmed:abstractText | Most HCO3- reabsorption in proximal tubules occurs via electroneutral Na+/H+ exchange in brush border membranes (BBMS) and electrogenic Na+:CO3=:HCO3- cotransport in basolateral membranes (BLMS). Since potassium depletion (KD) increases HCO3- reabsorption in proximal tubules, we evaluated these transport systems using BBM and BLM vesicles, respectively, from control (C) and KD rats. Feeding rats a potassium deficient diet for 3-4 wk resulted in lower plasma [K+] (2.94 mEq/liter, KD vs. 4.47 C), and higher arterial pH (7.51 KD vs. 7.39 C). KD rats gained less weight than C but had higher renal cortical weight. Influx of 1 mM 22Na+ at 5 s (pHo 7.5, pHi 6.0, 10% CO2, 90% N2) into BLM vesicles was 44% higher in the KD group compared to C with no difference in equilibrium uptake. The increment in Na+ influx in the KD group was DIDS sensitive, suggesting that Na+:CO3=:HCO3- cotransport accounted for the observed differences. Kinetic analysis of Na+ influx showed a Km of 8.2 mM in KD vs. 7.6 mM in C and Vmax of 278 nmol/min/mg protein in KD vs. 177 nmol/min/mg protein in C. Influx of 1 mM 22Na+ at 5 s (pHo 7.5, pHi 6.0) into BBM vesicles was 34% higher in the KD group compared to C with no difference in equilibrium uptake. The increment in Na+ influx in the KD group was amiloride sensitive, suggesting that Na+/H+ exchange was responsible for the observed differences. Kinetic analysis of Na+ influx showed a Km of 6.2 mM in KD vs. 7.1 mM in C and Vmax of 209 nmol/min/mg protein in KD vs. 144 nmol/min/mg protein in C. Uptakes of Na(+)-dependent [3H]glucose into BBM and [14C]succinate into BLM vesicles were not different in KD and C groups, suggesting that the Na+/H+ exchanger and Na+:CO3=:HCO3- cotransporter activities were specifically altered in KD. We conclude that adaptive increases in basolateral Na+:CO3=:HCO3- cotransport and luminal Na+H+ exchange are likely responsible for increased HCO3- reabsorption in proximal tubules of KD animals. | lld:pubmed |
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| pubmed-article:2170445 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2170445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2170445 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:2170445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2170445 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2170445 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:2170445 | pubmed:author | pubmed-author:McKinneyT DTD | lld:pubmed |
| pubmed-article:2170445 | pubmed:author | pubmed-author:SoleimaniMM | lld:pubmed |
| pubmed-article:2170445 | pubmed:author | pubmed-author:BergmanJ AJA | lld:pubmed |
| pubmed-article:2170445 | pubmed:author | pubmed-author:HosfordM AMA | lld:pubmed |
| pubmed-article:2170445 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2170445 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:2170445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2170445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2170445 | pubmed:pagination | 1076-83 | lld:pubmed |
| pubmed-article:2170445 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2170445 | pubmed:meshHeading | pubmed-meshheading:2170445-... | lld:pubmed |
| pubmed-article:2170445 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2170445 | pubmed:articleTitle | Potassium depletion increases luminal Na+/H+ exchange and basolateral Na+:CO3=:HCO3- cotransport in rat renal cortex. | lld:pubmed |
| pubmed-article:2170445 | pubmed:affiliation | Department of Medicine, Indiana University Medical Center, Indianapolis. | lld:pubmed |
| pubmed-article:2170445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2170445 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2170445 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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