| pubmed-article:2170113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2170113 | lifeskim:mentions | umls-concept:C0812246 | lld:lifeskim |
| pubmed-article:2170113 | lifeskim:mentions | umls-concept:C1710304 | lld:lifeskim |
| pubmed-article:2170113 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:2170113 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2170113 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:2170113 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2170113 | pubmed:dateCreated | 1990-11-15 | lld:pubmed |
| pubmed-article:2170113 | pubmed:abstractText | Differentiation Inducing Factor (DIF-1), a small chlorinated organic molecule which is produced during Dictyostelium development, is believed to be the morphogen that controls the stalk-specific pathway of differentiation. We describe the identification and characterization of a protease-sensitive activity from cell lysates which binds tritiated DIF-1 with the properties expected of a DIF receptor. Scatchard and linear subtraction plots show a single class of binding sites, of high affinity (Kd = 1.8 nM) and low abundance (1100 sites/cell). The activity elutes from heparin-agarose as a single peak. Various DIF-1 analogues compete for binding in proportion to their activities in a stalk cell differentiation bioassay. The amount of binding activity is developmentally regulated, peaking shortly before the appearance of the prestalk-prespore pattern and before the developmental rise in DIF concentration; the rise occurs at the same time that prestalk-specific genes become DIF inducible. Addition of cyclic AMP to aggregated cells, which induces post-aggregative gene expression in general, also induces the binding activity. | lld:pubmed |
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| pubmed-article:2170113 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2170113 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2170113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2170113 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2170113 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:2170113 | pubmed:author | pubmed-author:LINS CSC | lld:pubmed |
| pubmed-article:2170113 | pubmed:author | pubmed-author:InsallRR | lld:pubmed |
| pubmed-article:2170113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2170113 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:2170113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2170113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2170113 | pubmed:pagination | 3323-8 | lld:pubmed |
| pubmed-article:2170113 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2170113 | pubmed:meshHeading | pubmed-meshheading:2170113-... | lld:pubmed |
| pubmed-article:2170113 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2170113 | pubmed:articleTitle | A specific DIF binding protein in Dictyostelium. | lld:pubmed |
| pubmed-article:2170113 | pubmed:affiliation | MRC Laboratory of Molecular Biology, Cambridge, UK. | lld:pubmed |
| pubmed-article:2170113 | pubmed:publicationType | Journal Article | lld:pubmed |
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