| pubmed-article:21697469 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21697469 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:21697469 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:21697469 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:21697469 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:21697469 | pubmed:dateCreated | 2011-8-9 | lld:pubmed |
| pubmed-article:21697469 | pubmed:abstractText | v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP. Consistent with this, we show that v-Abl expression reduces levels of full-length p145 SHIP in a v-Abl kinase activity-dependent fashion. This event requires signals from the Abl SH2 domain but not the carboxyl terminus. Forced expression of full-length SHIP significantly reduces Ab-MLV pre-B-cell transformation. Therefore, reduction of SHIP protein by v-Abl is a critical component in Ab-MLV transformation. | lld:pubmed |
| pubmed-article:21697469 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21697469 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21697469 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21697469 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21697469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21697469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21697469 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21697469 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21697469 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21697469 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:21697469 | pubmed:author | pubmed-author:RosenbergNaom... | lld:pubmed |
| pubmed-article:21697469 | pubmed:author | pubmed-author:FesslerShawn... | lld:pubmed |
| pubmed-article:21697469 | pubmed:author | pubmed-author:BaughnLinda... | lld:pubmed |
| pubmed-article:21697469 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21697469 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:21697469 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21697469 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21697469 | pubmed:pagination | 9239-42 | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:meshHeading | pubmed-meshheading:21697469... | lld:pubmed |
| pubmed-article:21697469 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21697469 | pubmed:articleTitle | SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus. | lld:pubmed |
| pubmed-article:21697469 | pubmed:affiliation | Immunology Graduate Program, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. | lld:pubmed |
| pubmed-article:21697469 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21697469 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:16331 | entrezgene:pubmed | pubmed-article:21697469 | lld:entrezgene |
| entrez-gene:1491873 | entrezgene:pubmed | pubmed-article:21697469 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21697469 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21697469 | lld:entrezgene |
