| pubmed-article:21693215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C0022671 | lld:lifeskim |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C0001047 | lld:lifeskim |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C1704456 | lld:lifeskim |
| pubmed-article:21693215 | lifeskim:mentions | umls-concept:C1549464 | lld:lifeskim |
| pubmed-article:21693215 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21693215 | pubmed:dateCreated | 2011-6-22 | lld:pubmed |
| pubmed-article:21693215 | pubmed:abstractText | We investigated the effects of the antioxidant N-acetylcysteine (NAC) on early outcomes of deceased donor renal transplantation. Between April 2005 and June 2008, adult primary graft recipients of deceased renal donors were assigned to treatment (n = 38) or control (n = 36) groups and evaluated for 90 days and one year after renal transplantation. The treatment group received NAC orally (600 mg twice daily) from day 0 to 7 postoperatively. Renal function was determined by serum creatinine, MDRD and Cockcroft-Gault estimated GFR (eGFR), delayed graft function (DGF) and dialysis free Kaplan-Meier estimate curve. Serum levels of thiobarbituric acid reactive substances (TBARS), were employed as markers of oxidative stress. The NAC group displayed a lower mean serum creatinine during the first 90 days (P = .026) and at 1 year after transplantation (P = .005). Furthermore, the NAC group showed a higher mean eGFR throughout the first 90 days and at 1 year. DGF was lower among the NAC group (P = .017) and these recipients required fewer days of dialysis (P = .012). Oxidative stress was significantly attenuated with NAC (P < .001). Our results suggested that NAC enhanced early outcomes of deceased donor renal transplantation by attenuating oxidative stress. | lld:pubmed |
| pubmed-article:21693215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21693215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21693215 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21693215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21693215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21693215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21693215 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21693215 | pubmed:issn | 1873-2623 | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:SrougiMM | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:IanhezL ELE | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:LuconA MAM | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:SeguroA CAC | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:NahasW CWC | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:ShimizuM H... | lld:pubmed |
| pubmed-article:21693215 | pubmed:author | pubmed-author:DanilovicAA | lld:pubmed |
| pubmed-article:21693215 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21693215 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21693215 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:21693215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21693215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21693215 | pubmed:pagination | 1443-9 | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:meshHeading | pubmed-meshheading:21693215... | lld:pubmed |
| pubmed-article:21693215 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21693215 | pubmed:articleTitle | Protective effect of N-acetylcysteine on early outcomes of deceased renal transplantation. | lld:pubmed |
| pubmed-article:21693215 | pubmed:affiliation | Division of Urology, Department of Surgery, University of Sao Paulo General Hospital, Sao Paulo, Brazil. alexandre.danilovic@sbu.org.br | lld:pubmed |
| pubmed-article:21693215 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21693215 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
