pubmed-article:21690484 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:21690484 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
pubmed-article:21690484 | lifeskim:mentions | umls-concept:C0033497 | lld:lifeskim |
pubmed-article:21690484 | lifeskim:mentions | umls-concept:C1299624 | lld:lifeskim |
pubmed-article:21690484 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
pubmed-article:21690484 | lifeskim:mentions | umls-concept:C0220931 | lld:lifeskim |
pubmed-article:21690484 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:21690484 | pubmed:dateCreated | 2011-7-21 | lld:pubmed |
pubmed-article:21690484 | pubmed:abstractText | We have found recently that exercise training is effective in the treatment of the postural orthostatic tachycardia syndrome (POTS). Whether this nondrug treatment is superior to "standard" drug therapies, such as ?-blockade, is unknown. We tested the hypothesis that exercise training but not ?-blockade treatment improves symptoms, hemodynamics, and renal-adrenal responses in POTS patients. Nineteen patients (18 women and 1 man) completed a double-blind drug trial (propranolol or placebo) for 4 weeks, followed by 3 months of exercise training. Fifteen age-matched healthy individuals (14 women and 1 man) served as controls. A 2-hour standing test was performed before and after drug treatment and training. Hemodynamics, catecholamines, plasma renin activity, and aldosterone were measured supine and during 2-hour standing. We found that both propranolol and training significantly lowered standing heart rate. Standing cardiac output was lowered after propranolol treatment (P=0.01) but was minimally changed after training. The aldosterone:renin ratio during 2-hour standing remained unchanged after propranolol treatment (4.1±1.7 [SD] before versus 3.9±2.0 after; P=0.46) but modestly increased after training (5.2±2.9 versus 6.5±3.0; P=0.05). Plasma catecholamines were not affected by propranolol or training. Patient quality of life, assessed using the 36-item Short-Form Health Survey, was improved after training (physical functioning score 33±10 before versus 50±9 after; social functioning score 37±9 versus 48±6; both P<0.01) but not after propranolol treatment (34±10 versus 36±11, P=0.63; 39±7 versus 39±5, P=0.73). These results suggest that, for patients with POTS, exercise training is superior to propranolol at restoring upright hemodynamics, normalizing renal-adrenal responsiveness, and improving quality of life. | lld:pubmed |
pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:language | eng | lld:pubmed |
pubmed-article:21690484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:21690484 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:21690484 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:21690484 | pubmed:month | Aug | lld:pubmed |
pubmed-article:21690484 | pubmed:issn | 1524-4563 | lld:pubmed |
pubmed-article:21690484 | pubmed:author | pubmed-author:JoeL KLK | lld:pubmed |
pubmed-article:21690484 | pubmed:author | pubmed-author:LevineBenjami... | lld:pubmed |
pubmed-article:21690484 | pubmed:author | pubmed-author:WilliamsGordo... | lld:pubmed |
pubmed-article:21690484 | pubmed:author | pubmed-author:AuchusRichard... | lld:pubmed |
pubmed-article:21690484 | pubmed:author | pubmed-author:ShibataShigek... | lld:pubmed |
pubmed-article:21690484 | pubmed:author | pubmed-author:VangundyTiffa... | lld:pubmed |
pubmed-article:21690484 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:21690484 | pubmed:volume | 58 | lld:pubmed |
pubmed-article:21690484 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:21690484 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:21690484 | pubmed:pagination | 167-75 | lld:pubmed |
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pubmed-article:21690484 | pubmed:year | 2011 | lld:pubmed |
pubmed-article:21690484 | pubmed:articleTitle | Exercise training versus propranolol in the treatment of the postural orthostatic tachycardia syndrome. | lld:pubmed |
pubmed-article:21690484 | pubmed:affiliation | Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA. QiFu@TexasHealth.org | lld:pubmed |
pubmed-article:21690484 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:21690484 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:21690484 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
pubmed-article:21690484 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21690484 | lld:pubmed |