| pubmed-article:21685894 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21685894 | lifeskim:mentions | umls-concept:C1336596 | lld:lifeskim |
| pubmed-article:21685894 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:21685894 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21685894 | lifeskim:mentions | umls-concept:C1420631 | lld:lifeskim |
| pubmed-article:21685894 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:21685894 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:21685894 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21685894 | pubmed:dateCreated | 2011-7-4 | lld:pubmed |
| pubmed-article:21685894 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:abstractText | The co-occupancy of Tcf3 with Oct4, Sox2 and Nanog on embryonic stem cell (ESC) chromatin indicated that Tcf3 has been suggested to play an integral role in a poorly understood mechanism underlying Wnt-dependent stimulation of mouse ESC self-renewal of mouse ESCs. Although the conventional view of Tcf proteins as the ?-catenin-binding effectors of Wnt signalling suggested Tcf3-?-catenin activation of target genes would stimulate self-renewal, here we show that an antagonistic relationship between Wnt3a and Tcf3 on gene expression regulates ESC self-renewal. Genetic ablation of Tcf3 replaced the requirement for exogenous Wnt3a or GSK3 inhibition for ESC self-renewal, demonstrating that inhibition of Tcf3 repressor is the necessary downstream effect of Wnt signalling. Interestingly, both Tcf3-?-catenin and Tcf1-?-catenin interactions contributed to Wnt stimulation of self-renewal and gene expression, and the combination of Tcf3 and Tcf1 recruited Wnt-stabilized ?-catenin to Oct4 binding sites on ESC chromatin. This work elucidates the molecular link between the effects of Wnt and the regulation of the Oct4/Sox2/Nanog network. | lld:pubmed |
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| pubmed-article:21685894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21685894 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21685894 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21685894 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21685894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21685894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21685894 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21685894 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21685894 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21685894 | pubmed:issn | 1476-4679 | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:YuenCourtney... | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:LiuDavid RDR | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:PereiraLauraL | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:YiFeiF | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:MerrillBradle... | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:HoffmanJackso... | lld:pubmed |
| pubmed-article:21685894 | pubmed:author | pubmed-author:ShyBrian RBR | lld:pubmed |
| pubmed-article:21685894 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21685894 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:21685894 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21685894 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21685894 | pubmed:pagination | 762-70 | lld:pubmed |
| pubmed-article:21685894 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:21685894 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21685894 | pubmed:articleTitle | Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. | lld:pubmed |
| pubmed-article:21685894 | pubmed:affiliation | Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Avenue, MBRB 2270, M/C 669, Chicago, Illinois 60607, USA. | lld:pubmed |
| pubmed-article:21685894 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21685894 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21685894 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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