| pubmed-article:21679933 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C1325881 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:21679933 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21679933 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21679933 | pubmed:dateCreated | 2011-8-16 | lld:pubmed |
| pubmed-article:21679933 | pubmed:abstractText | This study describes the role of "inflammatory" oxidized (Ox) phospholipids in regulation of rahU (PA0122) expression and biofilm formation in Pseudomonas aeruginosa (383) wild type (rahU(+)) and rahU mutant (rahU(-)) strains. Functional analysis of RahU protein from P. aeruginosa in presence of Ox-phospholipids show: (a) LysoPC modulates RahU gene/and protein expression in rahU(+) cells; (b) rahU promoter activity is increased by lysoPC and inhibited by PAPC, Ox-PAPC and arachidonic acid; the latter inhibitory effect can be reversed by lysoPC, which was enzymatically derived from PAPC; (c) biofilm formation increased in rahU(-) cells as compared to rahU(+); and (d) inhibition of rahU promoter activity by PAPC and AA (but not lysoPC) showed significantly augmented biofilm formation in rahU(+) but not in rahU(-) cells. This study shows that host derived Ox-phospholipids affect P. aeruginosa-rahU gene and protein expression, which in turn modulates biofilm formation. The accompanying paper describes the role of RahU protein in eukaryotic-host cells. | lld:pubmed |
| pubmed-article:21679933 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21679933 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21679933 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21679933 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21679933 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21679933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21679933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21679933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21679933 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21679933 | pubmed:issn | 1090-2163 | lld:pubmed |
| pubmed-article:21679933 | pubmed:author | pubmed-author:GoldbergJoann... | lld:pubmed |
| pubmed-article:21679933 | pubmed:author | pubmed-author:LeitingerNorb... | lld:pubmed |
| pubmed-article:21679933 | pubmed:author | pubmed-author:AminAshok RAR | lld:pubmed |
| pubmed-article:21679933 | pubmed:author | pubmed-author:DiGiandomenic... | lld:pubmed |
| pubmed-article:21679933 | pubmed:author | pubmed-author:RaoJayasimhaJ | lld:pubmed |
| pubmed-article:21679933 | pubmed:author | pubmed-author:ArtamonovMykh... | lld:pubmed |
| pubmed-article:21679933 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21679933 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21679933 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:21679933 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21679933 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21679933 | pubmed:pagination | 95-102 | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:meshHeading | pubmed-meshheading:21679933... | lld:pubmed |
| pubmed-article:21679933 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21679933 | pubmed:articleTitle | Host derived inflammatory phospholipids regulate rahU (PA0122) gene, protein, and biofilm formation in Pseudomonas aeruginosa. | lld:pubmed |
| pubmed-article:21679933 | pubmed:affiliation | Research Department, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA 24013, USA. | lld:pubmed |
| pubmed-article:21679933 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21679933 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21679933 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:880611 | entrezgene:pubmed | pubmed-article:21679933 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21679933 | lld:entrezgene |
