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pubmed-article:21665462pubmed:abstractTextSecond-line treatment with irinotecan for advanced or metastatic colorectal cancer prolongs survival. It is uncertain whether irinotecan is better administered with 5-fluorouracil or alone in patients previously treated with a fluoropyrimidine. We compared toxicity (particularly diarrhoea), quality of life, and efficacy of combination chemotherapy and irinotecan in these patients.lld:pubmed
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pubmed-article:21665462pubmed:copyrightInfoCopyright © 2011 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21665462pubmed:articleTitleSingle-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis.lld:pubmed
pubmed-article:21665462pubmed:affiliationDepartment of Medicine, Concord Hospital, Concord, Sydney, Australia. stephen.clarke@sydney.edu.aulld:pubmed
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