| pubmed-article:21664132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0314787 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0020933 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0427978 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C1373040 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0281162 | lld:lifeskim |
| pubmed-article:21664132 | lifeskim:mentions | umls-concept:C0260127 | lld:lifeskim |
| pubmed-article:21664132 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:21664132 | pubmed:dateCreated | 2011-7-1 | lld:pubmed |
| pubmed-article:21664132 | pubmed:abstractText | The preparation and characterization of a series of thiophenyl oxime phosphonate beta-lactamase inhibitors is described. A number of these analogs were potent and selective inhibitors of class C beta-lactamases from Pseudomonas aeruginosa and Enterobacter cloacae. Compounds 3b and 7 reduced the MIC of imipenem against an AmpC expressing strain of imipenem-resistant P. aeruginosa. A number of the title compounds retained micromolar potency against the class D OXA-40 beta-lactamase from Acinetobacter baumannii and at high concentrations compound 3b was shown to reduce the MIC of imipenem against a highly imipenem-resistant strain of A. baumanii expressing the OXA-40 beta-lactamase. In mice compound 3b exhibited phamacokinetics similar to imipenem. | lld:pubmed |
| pubmed-article:21664132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21664132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21664132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21664132 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21664132 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:HammondMilton... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:WisniewskiDou... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:HermesJeffrey... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:YoungKatherin... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:ParkYoung-Wha... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:ColwellLawren... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:TanQiangQ | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:OgawaAimie... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:RaghoobarSusa... | lld:pubmed |
| pubmed-article:21664132 | pubmed:author | pubmed-author:DininnoFrank... | lld:pubmed |
| pubmed-article:21664132 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21664132 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21664132 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21664132 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21664132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21664132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21664132 | pubmed:pagination | 4363-5 | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:meshHeading | pubmed-meshheading:21664132... | lld:pubmed |
| pubmed-article:21664132 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21664132 | pubmed:articleTitle | Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii. | lld:pubmed |
| pubmed-article:21664132 | pubmed:affiliation | Department of Medicinal Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA. qiang_tan@merck.com | lld:pubmed |
| pubmed-article:21664132 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21664132 | lld:chembl |
