| pubmed-article:21658961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0053225 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0226896 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0205531 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C1527415 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0700307 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0470187 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:21658961 | lifeskim:mentions | umls-concept:C1512523 | lld:lifeskim |
| pubmed-article:21658961 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:21658961 | pubmed:dateCreated | 2011-6-24 | lld:pubmed |
| pubmed-article:21658961 | pubmed:abstractText | Based on the original spirodiketopiperazine design framework, further optimization of an orally available CCR5 antagonist was undertaken. Structural hybridization of the hydroxylated analog 4 derived from one of the oxidative metabolites and the new orally available non-hydroxylated benzoic acid analog 5 resulted in another potent orally available CCR5 antagonist 6a as a clinical candidate. Full details of a structure-activity relationship (SAR) study and ADME properties are presented. | lld:pubmed |
| pubmed-article:21658961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21658961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21658961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21658961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21658961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21658961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21658961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21658961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21658961 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21658961 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:MaedaKenjiK | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:MitsuyaHiroak... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:MurotaMasayuk... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:NakaiHisaoH | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:SagawaKenjiK | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:NishiyamaTosh... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:HisaichiKatsu... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:TakaokaYoshik... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:ShibayamaShir... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:FukushimaDaik... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:TadaHideakiH | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:NishizawaRena... | lld:pubmed |
| pubmed-article:21658961 | pubmed:author | pubmed-author:MinamotoChiak... | lld:pubmed |
| pubmed-article:21658961 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21658961 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21658961 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21658961 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:21658961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21658961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21658961 | pubmed:pagination | 4028-42 | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:meshHeading | pubmed-meshheading:21658961... | lld:pubmed |
| pubmed-article:21658961 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21658961 | pubmed:articleTitle | Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist. | lld:pubmed |
| pubmed-article:21658961 | pubmed:affiliation | Medicinal Chemistry Research Laboratory, Ono Pharmaceutical Co. Ltd, Shimamoto, Mishima, Osaka, Japan. r.nishizawa@ono.co.jp | lld:pubmed |
| pubmed-article:21658961 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21658961 | lld:chembl |
